A Conserved Tissue-Specific Homeodomain-Less Isoform of MEIS1 Is Downregulated in Colorectal Cancer

Richard C. Crist; Jacquelyn J. Roth; Scott A. Waldman; Arthur M. Buchberg

doi:10.1371/journal.pone.0023665

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Open Access

Peer-reviewed

Research Article

A Conserved Tissue-Specific Homeodomain-Less Isoform of MEIS1 Is Downregulated in Colorectal Cancer

Richard C. Crist,

Affiliation Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
⨯
Jacquelyn J. Roth,

Affiliation Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
⨯
Scott A. Waldman,

Affiliation Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
⨯
Arthur M. Buchberg

* E-mail: Arthur.Buchberg@jefferson.edu

Affiliation Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
⨯

A Conserved Tissue-Specific Homeodomain-Less Isoform of MEIS1 Is Downregulated in Colorectal Cancer

Richard C. Crist,
Jacquelyn J. Roth,
Scott A. Waldman,
Arthur M. Buchberg

Published: August 17, 2011
https://doi.org/10.1371/journal.pone.0023665

About the Authors

Richard C. Crist

Affiliation Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

Jacquelyn J. Roth

Affiliation Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

Scott A. Waldman

Affiliation Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

Arthur M. Buchberg

* E-mail: Arthur.Buchberg@jefferson.edu

Affiliation Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RCC JJR AMB. Performed the experiments: RCC. Analyzed the data: RCC JJR AMB. Contributed reagents/materials/analysis tools: SAW AMB. Wrote the paper: RCC AMB. Technical expertise: JJR SAW.

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Colon
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Colorectal cancer
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Homeobox
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Transcription factors
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Gastrointestinal cancers
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Epithelial cells
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DNA-binding proteins
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Carcinogenesis
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