About the Authors

Mitsuharu Matsumoto

m-matumoto@meito.co.jp

Affiliations Dairy Science and Technology Institute, Kyodo Milk Industry Co. Ltd., Tokyo, Japan, Benno Laboratory, Innovation Center, RIKEN, Wako, Japan

Shin Kurihara

Affiliations Division of Applied Biology, Graduate School of Science and Technology, Kyoto Institute of Technology, Kyoto, Japan, Division of Integrated Life Science, Graduate School of Biostudies, Kyoto University, Kyoto, Japan

Ryoko Kibe

Affiliation Benno Laboratory, Innovation Center, RIKEN, Wako, Japan

Hisashi Ashida

Affiliation Division of Integrated Life Science, Graduate School of Biostudies, Kyoto University, Kyoto, Japan

Yoshimi Benno

Affiliation Benno Laboratory, Innovation Center, RIKEN, Wako, Japan

Competing Interests

M. Matsumoto is an employee of and holds equity in Kyodo Milk Industry Co. Ltd. All of the other authors declare that they have no conflict of interest. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: MM. Performed the experiments: MM SK. Analyzed the data: MM SK. Contributed reagents/materials/analysis tools: MM. Wrote the paper: MM SK RK HA YB.