About the Authors

Yoko Honda

Affiliation Department of Genomics for Longevity and Health, Tokyo Metropolitan Institute of Gerontology, Sakaecho, Itabashiku, Tokyo, Japan

Yasunori Fujita

Affiliation Department of Longevity and Aging Research, Gifu International Institute of Biotechnology, Naka-fudogaoka, Kakamigahara, Gifu, Japan

Hiroe Maruyama

Affiliation API Company Limited, Nagaragawa Research Center, Nagarayamasaki, Gifu, Japan

Yoko Araki

Affiliation API Company Limited, Nagaragawa Research Center, Nagarayamasaki, Gifu, Japan

Kenji Ichihara

Affiliation API Company Limited, Nagaragawa Research Center, Nagarayamasaki, Gifu, Japan

Akira Sato

Affiliation Computational Systems Biology Research Group, Advanced Science Institute, RIKEN, Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, Japan

Toshio Kojima

Affiliations Computational Systems Biology Research Group, Advanced Science Institute, RIKEN, Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, Japan, Hamamatsu University School of Medicine, Handayama, Higashi-ku, Hamamatsu, Shizuoka, Japan

Masashi Tanaka

Affiliation Department of Genomics for Longevity and Health, Tokyo Metropolitan Institute of Gerontology, Sakaecho, Itabashiku, Tokyo, Japan

Yoshinori Nozawa

Affiliations Department of Longevity and Aging Research, Gifu International Institute of Biotechnology, Naka-fudogaoka, Kakamigahara, Gifu, Japan, Department of Food and Health, Tokai Gakuin University, Naka-kirinocho, Kakamigahara, Gifu, Japan

Masafumi Ito

Affiliation Department of Longevity and Aging Research, Gifu International Institute of Biotechnology, Naka-fudogaoka, Kakamigahara, Gifu, Japan

Shuji Honda

hondas@center.tmig.or.jp

Affiliation Department of Genomics for Longevity and Health, Tokyo Metropolitan Institute of Gerontology, Sakaecho, Itabashiku, Tokyo, Japan

Competing Interests

HM, YA and KI are employees of API Co., which engages in the manufacture and sale of royal jelly products and also provided the royal jelly used in this study. This is to confirm that the declaration does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: SH YH YF HM YA KI MI. Performed the experiments: YH YF HM SH YA AS TK MI. Analyzed the data: YH SH YF HM YA KI AS TK MT YN MI. Wrote the paper: SH YH MI YF HM YA KI TK.