About the Authors
- Ana M. Valdes
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* E-mail: ana.valdes@kcl.ac.uk
Affiliation Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom
- Unnur Styrkarsdottir
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Affiliation deCODE Genetics, Reykjavik, Iceland
- Michael Doherty
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Affiliation Academic Rheumatology, University of Nottingham, Nottingham, United Kingdom
- David L. Morris
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Affiliation Divisions of Genetics and Molecular Medicine and Immunology, Infection and Inflammatory Diseases, King's College London, London, United Kingdom
- Massimo Mangino
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Affiliation Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom
- Agu Tamm
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Affiliation Department of Internal Medicine, University of Tartu, Tartu, Estonia
- Sally A. Doherty
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Affiliation Academic Rheumatology, University of Nottingham, Nottingham, United Kingdom
- Kalle Kisand
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Affiliation Department of Internal Medicine, University of Tartu, Tartu, Estonia
- Irina Kerna
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Affiliation Department of Internal Medicine, University of Tartu, Tartu, Estonia
- Ann Tamm
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Affiliations Department of Internal Medicine, University of Tartu, Tartu, Estonia, Department of Sports Medicine and Rehabilitation, University of Tartu, Tartu, Estonia
- Margaret Wheeler
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Affiliation Academic Rheumatology, University of Nottingham, Nottingham, United Kingdom
- Rose A. Maciewicz
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Affiliation Respiratory & Inflammation Research Area, AstraZeneca, Loughborough, United Kingdom
- Weiya Zhang
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Affiliation Academic Rheumatology, University of Nottingham, Nottingham, United Kingdom
- Kenneth R. Muir
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Affiliation Health Sciences Research Institute, Warwick Medical School University of Warwick, Coventry, United Kingdom
- Elaine M. Dennison
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Affiliation Medical Research Council Lifecourse Epidemiology Unit University of Southampton Southampton, United Kingdom
- Deborah J. Hart
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Affiliation Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom
- Sarah Metrustry
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Affiliation Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom
- Ingileif Jonsdottir
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Affiliations deCODE Genetics, Reykjavik, Iceland, Faculty of Medicine, University of Iceland, Reykjavik, Iceland
- Gudbjorn F. Jonsson
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Affiliation deCODE Genetics, Reykjavik, Iceland
- Helgi Jonsson
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Affiliations Faculty of Medicine, University of Iceland, Reykjavik, Iceland, Department of Medicine, Landspitali University Hospital, Reykjavik, Iceland
- Thorvaldur Ingvarsson
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Affiliations Faculty of Medicine, University of Iceland, Reykjavik, Iceland, University Hospital, Institution of Health Science, University of Akureyri, Akureyri, Iceland
- Cyrus Cooper
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Affiliations Medical Research Council Lifecourse Epidemiology Unit University of Southampton Southampton, United Kingdom, Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, United Kingdom
- Timothy J. Vyse
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Affiliation Divisions of Genetics and Molecular Medicine and Immunology, Infection and Inflammatory Diseases, King's College London, London, United Kingdom
- Tim D. Spector
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Affiliation Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom
- Kari Stefansson
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Contributed equally to this work with: Kari Stefansson, Nigel K. Arden
Affiliations deCODE Genetics, Reykjavik, Iceland, Faculty of Medicine, University of Iceland, Reykjavik, Iceland
- Nigel K. Arden
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Contributed equally to this work with: Kari Stefansson, Nigel K. Arden
Affiliations Medical Research Council Lifecourse Epidemiology Unit University of Southampton Southampton, United Kingdom, Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, United Kingdom
Competing Interests
Dr. RA Maciewicz is employed by, owns stock and has patent applications for AstraZeneca. U. Styrkarsdottir, I. Jonsdottir, G. Jonsson and K. Stefansson are employed by deCODE Genetics. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials..
Author Contributions
Conceived and designed the experiments: AMV US MD DLM TDS KS NKA. Performed the experiments: SAD MW US KK IK AT SM. Analyzed the data: AMV US DLM MM. Contributed reagents/materials/analysis tools: MD AT RAM WZ KRM EMD DJH IJ GFJ HJ TI CC TJV TDS KS NKA. Wrote the paper: AMV US.