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Research Article

Combining Dynamic Stretch and Tunable Stiffness to Probe Cell Mechanobiology In Vitro

  • Angela M. Throm Quinlan,

    Affiliations: Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, Massachusetts, United States of America, Graduate School of Biomedical Sciences, UMass Medical School, Worcester, Massachusetts, United States of America

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  • Leslie N. Sierad,

    Affiliation: Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, Massachusetts, United States of America

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  • Andrew K. Capulli,

    Affiliation: Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, Massachusetts, United States of America

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  • Laura E. Firstenberg,

    Affiliation: Franklin W. Olin College of Engineering, Needham, Massachusetts, United States of America

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  • Kristen L. Billiar mail

    kbilliar@wpi.edu

    Affiliations: Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, Massachusetts, United States of America, Department of Surgery, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Published: August 15, 2011
  • DOI: 10.1371/journal.pone.0023272

About the Authors

Angela M. Throm Quinlan, Leslie N. Sierad, Andrew K. Capulli, Kristen L. Billiar
Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, Massachusetts, United States of America
Angela M. Throm Quinlan
Graduate School of Biomedical Sciences, UMass Medical School, Worcester, Massachusetts, United States of America
Laura E. Firstenberg
Franklin W. Olin College of Engineering, Needham, Massachusetts, United States of America
Kristen L. Billiar
Department of Surgery, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

Corresponding Author

Email: kbilliar@wpi.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KL AT LS. Performed the experiments: AT LS AC LF. Analyzed the data: AT LS AC LF KB. Contributed reagents/materials/analysis tools: AT AC LF LS. Wrote the paper: AT KB.