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Research Article

RIP1-Dependent and Independent Effects of Necrostatin-1 in Necrosis and T Cell Activation

  • YoungSik Cho equal contributor,

    equal contributor Contributed equally to this work with: YoungSik Cho, Thomas McQuade

    Affiliation: Department of Pathology, Program in Immunology and Virology, The University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

    Current address: College of Pharmacy, Keimyung University, Daegu, Korea

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  • Thomas McQuade equal contributor,

    equal contributor Contributed equally to this work with: YoungSik Cho, Thomas McQuade

    Affiliation: Department of Pathology, Program in Immunology and Virology, The University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Haibing Zhang,

    Affiliation: Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • Jianke Zhang,

    Affiliation: Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • Francis Ka-Ming Chan mail

    Francis.chan@umassmed.edu

    Affiliations: Department of Pathology, Program in Immunology and Virology, The University of Massachusetts Medical School, Worcester, Massachusetts, United States of America, UMass Diabetes and Endocrinology Research Center, The University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Published: August 10, 2011
  • DOI: 10.1371/journal.pone.0023209

About the Authors

YoungSik Cho, Thomas McQuade, Francis Ka-Ming Chan
Department of Pathology, Program in Immunology and Virology, The University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
Haibing Zhang, Jianke Zhang
Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
Francis Ka-Ming Chan
UMass Diabetes and Endocrinology Research Center, The University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

Corresponding Author

Email: Francis.chan@umassmed.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JZ FKMC. Performed the experiments: YC TM HZ JZ FKMC. Analyzed the data: YC HZ JZ FKMC. Wrote the paper: FKMC.