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Research Article

Drug-Resistant Genotypes and Multi-Clonality in Plasmodium falciparum Analysed by Direct Genome Sequencing from Peripheral Blood of Malaria Patients

  • Timothy Robinson equal contributor,

    equal contributor Contributed equally to this work with: Timothy Robinson, Susana G. Campino

    Affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

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  • Susana G. Campino equal contributor,

    equal contributor Contributed equally to this work with: Timothy Robinson, Susana G. Campino

    Affiliation: Wellcome Trust Sanger Institute, Hinxton, United Kingdom

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  • Sarah Auburn,

    Affiliations: Wellcome Trust Sanger Institute, Hinxton, United Kingdom, Global Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia

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  • Samuel A. Assefa,

    Affiliation: Wellcome Trust Sanger Institute, Hinxton, United Kingdom

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  • Spencer D. Polley,

    Affiliation: Department of Clinical Parasitology, Hospital for Tropical Diseases, London, United Kingdom

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  • Magnus Manske,

    Affiliation: Wellcome Trust Sanger Institute, Hinxton, United Kingdom

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  • Bronwyn MacInnis,

    Affiliations: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Wellcome Trust Sanger Institute, Hinxton, United Kingdom

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  • Kirk A. Rockett,

    Affiliations: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Wellcome Trust Sanger Institute, Hinxton, United Kingdom

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  • Gareth L. Maslen,

    Affiliation: Wellcome Trust Sanger Institute, Hinxton, United Kingdom

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  • Mandy Sanders,

    Affiliation: Wellcome Trust Sanger Institute, Hinxton, United Kingdom

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  • Michael A. Quail,

    Affiliation: Wellcome Trust Sanger Institute, Hinxton, United Kingdom

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  • Peter L. Chiodini,

    Affiliations: Department of Clinical Parasitology, Hospital for Tropical Diseases, London, United Kingdom, Faculties of Infectious and Tropical Diseases and Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, United Kingdom

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  • Dominic P. Kwiatkowski,

    Affiliations: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Wellcome Trust Sanger Institute, Hinxton, United Kingdom

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  • Taane G. Clark,

    Affiliation: Faculties of Infectious and Tropical Diseases and Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, United Kingdom

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  • Colin J. Sutherland mail

    colin.sutherland@lshtm.ac.uk

    Affiliations: Department of Clinical Parasitology, Hospital for Tropical Diseases, London, United Kingdom, Faculties of Infectious and Tropical Diseases and Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, United Kingdom

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  • Published: August 11, 2011
  • DOI: 10.1371/journal.pone.0023204

About the Authors

Timothy Robinson, Bronwyn MacInnis, Kirk A. Rockett, Dominic P. Kwiatkowski
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
Susana G. Campino, Sarah Auburn, Samuel A. Assefa, Magnus Manske, Bronwyn MacInnis, Kirk A. Rockett, Gareth L. Maslen, Mandy Sanders, Michael A. Quail, Dominic P. Kwiatkowski
Wellcome Trust Sanger Institute, Hinxton, United Kingdom
Sarah Auburn
Global Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia
Spencer D. Polley, Peter L. Chiodini, Colin J. Sutherland
Department of Clinical Parasitology, Hospital for Tropical Diseases, London, United Kingdom
Peter L. Chiodini, Taane G. Clark, Colin J. Sutherland
Faculties of Infectious and Tropical Diseases and Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, United Kingdom

Corresponding Author

Email: colin.sutherland@lshtm.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TR SGC SA DPK TGC CJS. Performed the experiments: TR SGC SA SAA SDP TGC CJS. Analyzed the data: SGC SA TGC CJS. Contributed reagents/materials/analysis tools: SGC SA MM BM KAR GLM MS MAQ DPK SDP PLC TGC CJS. Wrote the paper: TR TGC CJS. Revised and commented on the manuscript: SGC SA PLC.