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Research Article

Genomic Risk Profiling of Ischemic Stroke: Results of an International Genome-Wide Association Meta-Analysis

  • James F. Meschia mail,

    meschia.james@mayo.edu.

    Affiliation: Department of Neurology, Mayo Clinic, Jacksonville, Florida, United States of America

    X
  • Andrew Singleton,

    Affiliation: National Institute on Aging, Bethesda, Maryland, United States of America

    X
  • Michael A. Nalls,

    Affiliation: National Institute on Aging, Bethesda, Maryland, United States of America

    X
  • Stephen S. Rich,

    Affiliation: Departments of Public Health Sciences and the Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America

    X
  • Pankaj Sharma,

    Affiliation: Imperial College Cerebrovascular Research Unit (ICCRU), Imperial College London and Hammersmith Hospitals, London, United Kingdom

    X
  • Luigi Ferrucci,

    Affiliation: National Institute on Aging, Bethesda, Maryland, United States of America

    X
  • Mar Matarin,

    Affiliation: Department of Clinical and Experimental Epilepsy, University College of London Institute of Neurology, London, United Kingdom

    X
  • Dena G. Hernandez,

    Affiliation: National Institute on Aging, Bethesda, Maryland, United States of America

    X
  • Kerra Pearce,

    Affiliation: University College London Genomics and Institute of Child Health, London, United Kingdom

    X
  • Thomas G. Brott,

    Affiliation: Department of Neurology, Mayo Clinic, Jacksonville, Florida, United States of America

    X
  • Robert D. Brown Jr.,

    Affiliation: Department of Neurology, Mayo Clinic, Rochester, Minnesota, United States of America

    X
  • John Hardy,

    Affiliation: Department of Molecular Neuroscience Institute of Neurology, University College London, London, United Kingdom

    X
  • Bradford B. Worrall

    Affiliation: Departments of Neurology and Public Health Sciences, University of Virginia, Charlottesville, Virginia, United States of America

    X
  • Published: September 21, 2011
  • DOI: 10.1371/journal.pone.0023161

About the Authors

James F. Meschia, Thomas G. Brott
Department of Neurology, Mayo Clinic, Jacksonville, Florida, United States of America
Robert D. Brown Jr.
Department of Neurology, Mayo Clinic, Rochester, Minnesota, United States of America
John Hardy
Department of Molecular Neuroscience Institute of Neurology, University College London, London, United Kingdom
Andrew Singleton, Michael A. Nalls, Luigi Ferrucci, Dena G. Hernandez
National Institute on Aging, Bethesda, Maryland, United States of America
Stephen S. Rich
Departments of Public Health Sciences and the Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America
Pankaj Sharma
Imperial College Cerebrovascular Research Unit (ICCRU), Imperial College London and Hammersmith Hospitals, London, United Kingdom
Mar Matarin
Department of Clinical and Experimental Epilepsy, University College of London Institute of Neurology, London, United Kingdom
Kerra Pearce
University College London Genomics and Institute of Child Health, London, United Kingdom
Bradford B. Worrall
Departments of Neurology and Public Health Sciences, University of Virginia, Charlottesville, Virginia, United States of America

Corresponding Author

Email: meschia.james@mayo.edu.

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JFM PS MAN SSR AS JH. Performed the experiments: JFM AS MAN KP DH MM. Analyzed the data: MAN SSR. Contributed reagents/materials/analysis tools: JFM AS MAN SSR PS LF MM DGH KP TGB RDB JH BBW. Wrote the paper: JFM AS MAN PS SSR MM DGH KP TGB RDB JH BBW.