About the Authors

Marinella G. Callow

Affiliation Department of Cancer Targets, Genentech Research and Early Development, South San Francisco, California, United States of America

Hoanh Tran

Affiliation Department of Cancer Targets, Genentech Research and Early Development, South San Francisco, California, United States of America

Lilian Phu

Affiliation Department of Protein Chemistry, Genentech Research and Early Development, South San Francisco, California, United States of America

Ted Lau

Affiliation Department of Cancer Targets, Genentech Research and Early Development, South San Francisco, California, United States of America

James Lee

Affiliation Department of Discovery Oncology, Genentech Research and Early Development, South San Francisco, California, United States of America

Wendy N. Sandoval

Affiliation Department of Protein Chemistry, Genentech Research and Early Development, South San Francisco, California, United States of America

Peter S. Liu

Affiliation Department of Protein Chemistry, Genentech Research and Early Development, South San Francisco, California, United States of America

Sheila Bheddah

Affiliation Department of Research Pathology, Genentech Research and Early Development, South San Francisco, California, United States of America

Janet Tao

Affiliation Department of Research Pathology, Genentech Research and Early Development, South San Francisco, California, United States of America

Jennie R. Lill

Affiliation Department of Protein Chemistry, Genentech Research and Early Development, South San Francisco, California, United States of America

Jo-Anne Hongo

Affiliation Department of Antibody Engineering, Genentech Research and Early Development, South San Francisco, California, United States of America

David Davis

Affiliation Department of Discovery Oncology, Genentech Research and Early Development, South San Francisco, California, United States of America

Donald S. Kirkpatrick

Affiliation Department of Protein Chemistry, Genentech Research and Early Development, South San Francisco, California, United States of America

Paul Polakis

Affiliation Department of Cancer Targets, Genentech Research and Early Development, South San Francisco, California, United States of America

Mike Costa

mcosta@gene.com

Affiliation Department of Cancer Targets, Genentech Research and Early Development, South San Francisco, California, United States of America

Competing Interests

The authors have read the journal's policy and have the following conflicts. All authors are employed by Genentech Research and Early Development. There are no patents, products in development, or marketed products to declare for this manuscript. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: MGC HT DSK PP MC JRL JAH DD. Performed the experiments: MGC HT LP TL WNS PSL SB JT JL MC. Analyzed the data: MGC HT LP TL JL WNS PSL SB JT JRL JAH DD DSK PP MC. Wrote the paper: MGC WNS JRL DSK MC.