About the Authors

Wanyang Liu

Contributed equally to this work with: Wanyang Liu, Daisuke Morito, Seiji Takashima, Yohei Mineharu, Hatasu Kobayashi, Toshiaki Hitomi, Hirokuni Hashikata, Norio Matsuura

Affiliation Department of Health and Environmental Sciences, Kyoto University, Kyoto, Japan

Daisuke Morito

Contributed equally to this work with: Wanyang Liu, Daisuke Morito, Seiji Takashima, Yohei Mineharu, Hatasu Kobayashi, Toshiaki Hitomi, Hirokuni Hashikata, Norio Matsuura

Affiliation Faculty of Life Sciences, Kyoto Sangyo University, Kyoto, Japan

Seiji Takashima

Contributed equally to this work with: Wanyang Liu, Daisuke Morito, Seiji Takashima, Yohei Mineharu, Hatasu Kobayashi, Toshiaki Hitomi, Hirokuni Hashikata, Norio Matsuura

Affiliation Department of Molecular Cardiology, Osaka University, Suita, Osaka, Japan

Yohei Mineharu

Contributed equally to this work with: Wanyang Liu, Daisuke Morito, Seiji Takashima, Yohei Mineharu, Hatasu Kobayashi, Toshiaki Hitomi, Hirokuni Hashikata, Norio Matsuura

Affiliation Department of Neurosurgery, Kyoto University, Kyoto, Japan

Hatasu Kobayashi

Contributed equally to this work with: Wanyang Liu, Daisuke Morito, Seiji Takashima, Yohei Mineharu, Hatasu Kobayashi, Toshiaki Hitomi, Hirokuni Hashikata, Norio Matsuura

Affiliation Department of Health and Environmental Sciences, Kyoto University, Kyoto, Japan

Toshiaki Hitomi

Contributed equally to this work with: Wanyang Liu, Daisuke Morito, Seiji Takashima, Yohei Mineharu, Hatasu Kobayashi, Toshiaki Hitomi, Hirokuni Hashikata, Norio Matsuura

Affiliation Department of Health and Environmental Sciences, Kyoto University, Kyoto, Japan

Hirokuni Hashikata

Contributed equally to this work with: Wanyang Liu, Daisuke Morito, Seiji Takashima, Yohei Mineharu, Hatasu Kobayashi, Toshiaki Hitomi, Hirokuni Hashikata, Norio Matsuura

Affiliations Department of Health and Environmental Sciences, Kyoto University, Kyoto, Japan, Department of Neurosurgery, Kyoto University, Kyoto, Japan

Norio Matsuura

Contributed equally to this work with: Wanyang Liu, Daisuke Morito, Seiji Takashima, Yohei Mineharu, Hatasu Kobayashi, Toshiaki Hitomi, Hirokuni Hashikata, Norio Matsuura

Affiliation Department of Health and Environmental Sciences, Kyoto University, Kyoto, Japan

Satoru Yamazaki

Affiliation National Cerebral and Cardiovascular Center, Suita, Osaka, Japan

Atsushi Toyoda

Affiliation Comparative Genomics Laboratory, National Institute of Genetics, Mishima, Shizuoka, Japan

Ken-ichiro Kikuta

Affiliation Department of Neurosurgery, Kyoto University, Kyoto, Japan

Yasushi Takagi

Affiliation Department of Neurosurgery, Kyoto University, Kyoto, Japan

Kouji H. Harada

Affiliation Department of Health and Environmental Sciences, Kyoto University, Kyoto, Japan

Asao Fujiyama

Affiliations Comparative Genomics Laboratory, National Institute of Genetics, Mishima, Shizuoka, Japan, Principles of Informatics Research Division, National Institute of Informatics, Tokyo, Japan

Roman Herzig

Affiliation Palacky University Hospital, Olomouc, Czech Republic

Boris Krischek

Affiliation Department of Neurosurgery, University of Tubingen, Tubingen, Germany

Liping Zou

Affiliation Department of Pediatrics, Chinese People's Liberation Army General Hospital, Beijing, People's Republic of China

Jeong Eun Kim

Affiliation Seoul National University College of Medicine, Seoul, Korea

Masafumi Kitakaze

Affiliation National Cerebral and Cardiovascular Center, Suita, Osaka, Japan

Susumu Miyamoto

Affiliation Department of Neurosurgery, Kyoto University, Kyoto, Japan

Kazuhiro Nagata

Affiliation Faculty of Life Sciences, Kyoto Sangyo University, Kyoto, Japan

Nobuo Hashimoto

hashimot@hsp.ncvc.go.jp (NH); koizumi.akio.5v@kyoto-u.ac.jp (AK)

Affiliations Department of Neurosurgery, Kyoto University, Kyoto, Japan, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan

Akio Koizumi

hashimot@hsp.ncvc.go.jp (NH); koizumi.akio.5v@kyoto-u.ac.jp (AK)

Affiliation Department of Health and Environmental Sciences, Kyoto University, Kyoto, Japan

Competing Interests

Kyoto University has applied to the Patent Office, Japan, for a patent on this gene. The authors confirm that this does not alter their adherence to all the PLos One policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: AK. Performed the experiments: AK WL DM ST HK TH NM SY AT AF. Contributed reagents/materials/analysis tools: NH WL YM HH KK YT RH BK LZ JEK SM. Wrote the paper: AK NH WL DM ST YM HK TH HH SY KHH MK SM KN. Analyzed the genetic data: AK WL NM KHH AT AF. Analyzed the clinical data: NH YM HH KK YT RH BK LZ JEK MK SM. Analyzed the molecular data: DM ST HK TH SY KN. All authors have read and approved submission of the manuscript.