Advertisement
Research Article

High Resolution Detection and Analysis of CpG Dinucleotides Methylation Using MBD-Seq Technology

  • Xun Lan,

    Affiliation: Department of Biomedical Informatics, The Ohio State University, Columbus, Ohio, United States of America

    X
  • Christopher Adams,

    Affiliation: Life Technologies, Carlsbad, California, United States of America

    X
  • Mark Landers,

    Affiliation: Life Technologies, Carlsbad, California, United States of America

    X
  • Miroslav Dudas,

    Affiliation: Life Technologies, Carlsbad, California, United States of America

    X
  • Daniel Krissinger,

    Affiliation: Life Technologies, Carlsbad, California, United States of America

    X
  • George Marnellos,

    Affiliation: Life Technologies, Carlsbad, California, United States of America

    X
  • Russell Bonneville,

    Affiliation: Department of Biomedical Informatics, The Ohio State University, Columbus, Ohio, United States of America

    X
  • Maoxiong Xu,

    Affiliation: Department of Biomedical Informatics, The Ohio State University, Columbus, Ohio, United States of America

    X
  • Junbai Wang,

    Affiliation: Department of Pathology, The Norwegian Radium Hospital, Oslo University, Oslo, Norway

    X
  • Tim H.-M. Huang,

    Affiliation: Human Cancer Genetics Program, The Ohio State University, Columbus, Ohio, United States of America

    X
  • Gavin Meredith,

    Affiliation: Life Technologies, Carlsbad, California, United States of America

    X
  • Victor X. Jin mail

    victor.jin@osumc.edu

    Affiliation: Department of Biomedical Informatics, The Ohio State University, Columbus, Ohio, United States of America

    X
  • Published: July 11, 2011
  • DOI: 10.1371/journal.pone.0022226

About the Authors

Xun Lan, Russell Bonneville, Maoxiong Xu, Victor X. Jin
Department of Biomedical Informatics, The Ohio State University, Columbus, Ohio, United States of America
Christopher Adams, Mark Landers, Miroslav Dudas, Daniel Krissinger, George Marnellos, Gavin Meredith
Life Technologies, Carlsbad, California, United States of America
Junbai Wang
Department of Pathology, The Norwegian Radium Hospital, Oslo University, Oslo, Norway
Tim H.-M. Huang
Human Cancer Genetics Program, The Ohio State University, Columbus, Ohio, United States of America

Corresponding Author

Email: victor.jin@osumc.edu

Competing Interests

The authors CA, ML, MD, DK, G. Marnellos, G. Meredith are employed at Life Technologies. The others are from OSU and have no roles at Life Tech. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: XL VXJ. Performed the experiments: XL CA G. Marnellos G. Meredith RB MX JW TH VXJ. Analyzed the data: XL RB MX JW VXJ. Contributed reagents/materials/analysis tools: CA ML MD DK G. Marnellos G. Meredith. Wrote the paper: XL VXJ.