Network Neighbors of Drug Targets Contribute to Drug Side-Effect Similarity

Lucas Brouwers; Murat Iskar; Georg Zeller; Vera van Noort; Peer Bork

doi:10.1371/journal.pone.0022187

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Open Access

Peer-reviewed

Research Article

Network Neighbors of Drug Targets Contribute to Drug Side-Effect Similarity

Lucas Brouwers,

Affiliation Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
⨯
Murat Iskar,

Affiliation Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
⨯
Georg Zeller,

Affiliation Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
⨯
Vera van Noort,

Affiliation Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
⨯
Peer Bork

* E-mail: bork@embl.de

Affiliations Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany, Max-Delbruck-Centre for Molecular Medicine, Berlin-Buch, Germany
⨯

Network Neighbors of Drug Targets Contribute to Drug Side-Effect Similarity

Lucas Brouwers,
Murat Iskar,
Georg Zeller,
Vera van Noort,
Peer Bork

Published: July 13, 2011
https://doi.org/10.1371/journal.pone.0022187

About the Authors

Lucas Brouwers

Affiliation Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany

Murat Iskar

Affiliation Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany

Georg Zeller

Affiliation Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany

Vera van Noort

Affiliation Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany

Peer Bork

* E-mail: bork@embl.de

Affiliations Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany, Max-Delbruck-Centre for Molecular Medicine, Berlin-Buch, Germany

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PB VN. Performed the experiments: LB MI GZ. Analyzed the data: LB MI GZ. Wrote the paper: LB MI GZ VN PB.

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Adverse reactions
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Protein interaction networks
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Drug discovery
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Drug interactions
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Adverse events
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Protein-protein interactions
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Drug metabolism
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Protein interactions
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