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Research Article

GATA6 Activates Wnt Signaling in Pancreatic Cancer by Negatively Regulating the Wnt Antagonist Dickkopf-1

  • Yi Zhong equal contributor,

    equal contributor Contributed equally to this work with: Yi Zhong, Zheng Wang

    Affiliation: Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America

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  • Zheng Wang equal contributor,

    equal contributor Contributed equally to this work with: Yi Zhong, Zheng Wang

    Affiliations: Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America, Department of Hepatobiliary Surgery, The First Affiliated Hospital, School of Medicine of Xi'an Jiaotong University, Shanxi, China

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  • Baojin Fu,

    Affiliation: Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America

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  • Fan Pan,

    Affiliation: Department of Oncology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America

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  • Shinichi Yachida,

    Affiliation: Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America

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  • Mousumi Dhara,

    Affiliation: Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America

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  • Emilia Albesiano,

    Affiliation: Department of Oncology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America

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  • Li Li,

    Affiliations: Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America, Department of Opthamology, The First Affiliated Hospital, School of Medicine of Xi'an Jiaotong University, Shanxi, China

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  • Yoshiki Naito,

    Affiliation: Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America

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  • Felip Vilardell,

    Affiliations: Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America, Hospital Universitari Arnau de Vilanova, Lleida, Spain

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  • Christopher Cummings,

    Affiliations: Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America, University of Colorado School of Medicine, Denver, Colorado, United States of America

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  • Paola Martinelli,

    Affiliation: Programa de Patologia Molecular, Centro Nacional de Investigaciones Oncológicas, Madrid, Spain

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  • Ang Li,

    Affiliation: Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America

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  • Raluca Yonescu,

    Affiliation: Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America

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  • Qingyong Ma,

    Affiliation: Department of Hepatobiliary Surgery, The First Affiliated Hospital, School of Medicine of Xi'an Jiaotong University, Shanxi, China

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  • Constance A. Griffin,

    Affiliations: Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America, Department of Oncology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America

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  • Francisco X. Real,

    Affiliations: Programa de Patologia Molecular, Centro Nacional de Investigaciones Oncológicas, Madrid, Spain, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain

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  • Christine A. Iacobuzio-Donahue mail

    ciacobu@jhmi.edu

    Affiliations: Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America, Department of Oncology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America, Department of Surgery, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America

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  • Published: July 19, 2011
  • DOI: 10.1371/journal.pone.0022129

About the Authors

Yi Zhong, Zheng Wang, Baojin Fu, Shinichi Yachida, Mousumi Dhara, Li Li, Yoshiki Naito, Felip Vilardell, Christopher Cummings, Ang Li, Raluca Yonescu, Constance A. Griffin, Christine A. Iacobuzio-Donahue
Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America
Fan Pan, Emilia Albesiano, Constance A. Griffin, Christine A. Iacobuzio-Donahue
Department of Oncology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America
Christine A. Iacobuzio-Donahue
Department of Surgery, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America
Christopher Cummings
University of Colorado School of Medicine, Denver, Colorado, United States of America
Felip Vilardell
Hospital Universitari Arnau de Vilanova, Lleida, Spain
Paola Martinelli, Francisco X. Real
Programa de Patologia Molecular, Centro Nacional de Investigaciones Oncológicas, Madrid, Spain
Zheng Wang, Qingyong Ma
Department of Hepatobiliary Surgery, The First Affiliated Hospital, School of Medicine of Xi'an Jiaotong University, Shanxi, China
Li Li
Department of Opthamology, The First Affiliated Hospital, School of Medicine of Xi'an Jiaotong University, Shanxi, China
Francisco X. Real
Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain

Corresponding Author

Email: ciacobu@jhmi.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: YZ ZW BF FP EA PM QM CAG FXR CAI-D. Performed the experiments: YZ ZW BF FP SY MD EA LL YN FV CC AL RY. Analyzed the data: YZ ZW BF FP SY MD EA LL YN FV RY CAI-D. Contributed reagents/materials/analysis tools: YZ ZW BF FP SY MD EA LL YN FV CC AL RY QM CAG FXR CAI-D. Wrote the paper: YZ ZW BF CAI-D.