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Research Article

A Novel Role of Protein Tyrosine Kinase2 in Mediating Chloride Secretion in Human Airway Epithelial Cells

  • Lihua Liang,

    Affiliation: Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland

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  • Owen M. Woodward,

    Affiliation: Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland

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  • Zhaohui Chen,

    Affiliation: Department of Pharmacology and Molecular Science, Johns Hopkins University School of Medicine, Baltimore, Maryland

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  • Robert Cotter,

    Affiliation: Department of Pharmacology and Molecular Science, Johns Hopkins University School of Medicine, Baltimore, Maryland

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  • William B. Guggino mail

    wguggino@jhmi.edu.

    Affiliation: Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland

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  • Published: July 13, 2011
  • DOI: 10.1371/journal.pone.0021991

About the Authors

Lihua Liang, Owen M. Woodward, William B. Guggino
Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland
Zhaohui Chen, Robert Cotter
Department of Pharmacology and Molecular Science, Johns Hopkins University School of Medicine, Baltimore, Maryland

Corresponding Author

Email: wguggino@jhmi.edu.

Competing Interests

The authors filed a provisional application (C10156: Spiperone: A Novel Cystic Fibrosis Therapeutic Agent Identified By High Throughput Screening) which was essentially a short write-up and data. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials, as detailed online in the PLoS One guide for authors. It should be mentioned that the authors have received no financial reward in association with the provisional patent.

Author Contributions

Conceived and designed the experiments: LL WBG. Performed the experiments: LL OMW ZC. Analyzed the data: LL OMW WBG. Contributed reagents/materials/analysis tools: RC WBG. Wrote the paper: LL WBG.