About the Authors

Masamitsu Oshima

Contributed equally to this work with: Masamitsu Oshima, Mitsumasa Mizuno

Affiliation Research Institute for Science and Technology, Tokyo University of Science, Noda, Chiba, Japan

Mitsumasa Mizuno

Contributed equally to this work with: Masamitsu Oshima, Mitsumasa Mizuno

Affiliations Research Institute for Science and Technology, Tokyo University of Science, Noda, Chiba, Japan, Division of Orthodontics and Dentofacial Orthopedics, Graduate School of Dentistry, Tohoku University, Sendai, Miyagi, Japan

Aya Imamura

Affiliation Department of Biological Science and Technology, Graduate School of Industrial Science and Technology, Tokyo University of Science, Noda, Chiba, Japan

Miho Ogawa

Affiliations Research Institute for Science and Technology, Tokyo University of Science, Noda, Chiba, Japan, Organ Technologies Inc., Tokyo, Japan

Masato Yasukawa

Affiliation Department of Biological Science and Technology, Graduate School of Industrial Science and Technology, Tokyo University of Science, Noda, Chiba, Japan

Hiromichi Yamazaki

Affiliation Department of Biological Science and Technology, Graduate School of Industrial Science and Technology, Tokyo University of Science, Noda, Chiba, Japan

Ritsuko Morita

Affiliation Research Institute for Science and Technology, Tokyo University of Science, Noda, Chiba, Japan

Etsuko Ikeda

Affiliation Division of Orthodontics and Dentofacial Orthopedics, Graduate School of Dentistry, Tohoku University, Sendai, Miyagi, Japan

Kazuhisa Nakao

Affiliation Research Institute for Science and Technology, Tokyo University of Science, Noda, Chiba, Japan

Teruko Takano-Yamamoto

Affiliation Division of Orthodontics and Dentofacial Orthopedics, Graduate School of Dentistry, Tohoku University, Sendai, Miyagi, Japan

Shohei Kasugai

Affiliation Oral Implantology and Regenerative Dental Medicine Graduate School, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan

Masahiro Saito

Affiliations Research Institute for Science and Technology, Tokyo University of Science, Noda, Chiba, Japan, Department of Biological Science and Technology, Graduate School of Industrial Science and Technology, Tokyo University of Science, Noda, Chiba, Japan

Takashi Tsuji

t-tsuji@rs.noda.tus.ac.jp

Affiliations Research Institute for Science and Technology, Tokyo University of Science, Noda, Chiba, Japan, Department of Biological Science and Technology, Graduate School of Industrial Science and Technology, Tokyo University of Science, Noda, Chiba, Japan, Organ Technologies Inc., Tokyo, Japan

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Performed the experiments: M. Oshima MM MY KN. Analyzed the data: AI M. Ogawa HY. Wrote the paper: M. Oshima TT. Designed the research plan: TT M. Oshima. Developed new assay systems and the discussion of the results: M. Ogawa RM EI TT-Y SK MS.