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Research Article

Cambogin Is Preferentially Cytotoxic to Cells Expressing PDGFR

  • Ze Tian mail,

    ze_tian@dfci.harvard.edu (ZT); erxi.wu@ndsu.edu (EW)

    Affiliations: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China, Informatics Program, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Jie Shen,

    Affiliation: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China

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  • Fengfei Wang,

    Affiliation: Department of Pharmaceutical Sciences, North Dakota State University, Fargo, North Dakota, United States of America

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  • Peigen Xiao,

    Affiliation: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China

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  • Junshan Yang,

    Affiliation: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China

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  • Hetian Lei,

    Affiliations: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China, Department of Ophthalmology, Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Andrius Kazlauskas,

    Affiliation: Department of Ophthalmology, Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Isaac S. Kohane,

    Affiliation: Informatics Program, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Erxi Wu mail

    ze_tian@dfci.harvard.edu (ZT); erxi.wu@ndsu.edu (EW)

    Affiliation: Department of Pharmaceutical Sciences, North Dakota State University, Fargo, North Dakota, United States of America

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  • Published: June 21, 2011
  • DOI: 10.1371/journal.pone.0021370

About the Authors

Ze Tian, Jie Shen, Peigen Xiao, Junshan Yang, Hetian Lei
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
Fengfei Wang, Erxi Wu
Department of Pharmaceutical Sciences, North Dakota State University, Fargo, North Dakota, United States of America
Hetian Lei, Andrius Kazlauskas
Department of Ophthalmology, Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts, United States of America
Ze Tian, Isaac S. Kohane
Informatics Program, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ZT EW. Performed the experiments: ZT JS FW EW. Analyzed the data: ZT JS FW HL EW. Contributed reagents/materials/analysis tools: ZT JS FW PX JY AK ISK EW. Wrote the paper: ZT EW.