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Research Article

Deterministic and Stochastic Allele Specific Gene Expression in Single Mouse Blastomeres

  • Fuchou Tang equal contributor,

    equal contributor Contributed equally to this work with: Fuchou Tang, Catalin Barbacioru

    Affiliations: Wellcome Trust/Cancer Research UK Gurdon Institute of Cancer and Developmental Biology, University of Cambridge, Cambridge, United Kingdom, Biodynamic Optical Imaging Center, School of Life Sciences, Peking University, Beijing, China

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  • Catalin Barbacioru equal contributor,

    equal contributor Contributed equally to this work with: Fuchou Tang, Catalin Barbacioru

    Affiliation: Genetic Systems, Applied Biosystems, Life Technologies, Foster City, California, United States of America

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  • Ellen Nordman,

    Affiliation: Genetic Systems, Applied Biosystems, Life Technologies, Foster City, California, United States of America

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  • Siqin Bao,

    Affiliation: Wellcome Trust/Cancer Research UK Gurdon Institute of Cancer and Developmental Biology, University of Cambridge, Cambridge, United Kingdom

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  • Caroline Lee,

    Affiliation: Wellcome Trust/Cancer Research UK Gurdon Institute of Cancer and Developmental Biology, University of Cambridge, Cambridge, United Kingdom

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  • Xiaohui Wang,

    Affiliation: Genetic Systems, Applied Biosystems, Life Technologies, Foster City, California, United States of America

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  • Brian B. Tuch,

    Affiliation: Genetic Systems, Applied Biosystems, Life Technologies, Foster City, California, United States of America

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  • Edith Heard,

    Affiliation: CNRS UMR3215, INSERM U934, Institut Curie, Paris, France

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  • Kaiqin Lao mail,

    a.surani@gurdon.cam.ac.uk (MAS); kaiqinlao@gmail.com (KL)

    Affiliation: Genetic Systems, Applied Biosystems, Life Technologies, Foster City, California, United States of America

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  • M. Azim Surani mail

    a.surani@gurdon.cam.ac.uk (MAS); kaiqinlao@gmail.com (KL)

    Affiliation: Wellcome Trust/Cancer Research UK Gurdon Institute of Cancer and Developmental Biology, University of Cambridge, Cambridge, United Kingdom

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  • Published: June 23, 2011
  • DOI: 10.1371/journal.pone.0021208

About the Authors

Fuchou Tang, Siqin Bao, Caroline Lee, M. Azim Surani
Wellcome Trust/Cancer Research UK Gurdon Institute of Cancer and Developmental Biology, University of Cambridge, Cambridge, United Kingdom
Catalin Barbacioru, Ellen Nordman, Xiaohui Wang, Brian B. Tuch, Kaiqin Lao
Genetic Systems, Applied Biosystems, Life Technologies, Foster City, California, United States of America
Fuchou Tang
Biodynamic Optical Imaging Center, School of Life Sciences, Peking University, Beijing, China
Edith Heard
CNRS UMR3215, INSERM U934, Institut Curie, Paris, France

Corresponding Authors

Competing Interests

KL, CB, EN, XW, BT are employees of Life Technologies Corporation.

Author Contributions

Conceived and designed the experiments: KL MAS FT. Analyzed the data: KL MAS EH FT CB. Wrote the paper: KL MAS EH FT. Sample preparation and sequencing: FT EN SB CL. Bioinformatics analysis: CB KL XW BBT.