About the Authors

Yazmin Macotela

Affiliation Joslin Diabetes Center and Harvard Medical School, Boston, Massachusetts, United States of America

Brice Emanuelli

Affiliation Joslin Diabetes Center and Harvard Medical School, Boston, Massachusetts, United States of America

Anneli M. Bång

Affiliation Joslin Diabetes Center and Harvard Medical School, Boston, Massachusetts, United States of America

Daniel O. Espinoza

Affiliation Joslin Diabetes Center and Harvard Medical School, Boston, Massachusetts, United States of America

Jeremie Boucher

Affiliation Joslin Diabetes Center and Harvard Medical School, Boston, Massachusetts, United States of America

Kirk Beebe

Affiliation Metabolon, Inc., Durham, North Carolina, United States of America

Walter Gall

Affiliation Metabolon, Inc., Durham, North Carolina, United States of America

C. Ronald Kahn

c.ronald.kahn@joslin.harvard.edu

Affiliation Joslin Diabetes Center and Harvard Medical School, Boston, Massachusetts, United States of America

Competing Interests

Metabolon Inc acted as a funder only through employment of KB and WG. The role of Metabolon was performance of the metabolomic analysis reported in this study. Other than that, Metabolon had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. This was strictly controlled by the academic team and free of any competing interest. Besides KB and GW being employees of Metabolon, Inc, the authors have no other affiliations to this company, neither through employment, consulting, patents, marketing products, etc. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: YM BE CRK. Performed the experiments: YM BE AMB DOE JB KB WG. Analyzed the data: YM BE AMB DOE JB KB WG CRK. Contributed reagents/materials/analysis tools: KB WG CRK. Wrote the paper: YM CRK.