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Research Article

Control of Kaposi's Sarcoma-Associated Herpesvirus Reactivation Induced by Multiple Signals

  • Fuqu Yu equal contributor,

    equal contributor Contributed equally to this work with: Fuqu Yu, Ibrahim Al-Shyoukh

    Affiliation: Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California, United States of America

    Current address: Johnson & Johnson Pharmaceutical Research & Development LLC, San Diego, California, United States of America,

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  • Ibrahim Al-Shyoukh equal contributor,

    equal contributor Contributed equally to this work with: Fuqu Yu, Ibrahim Al-Shyoukh

    Affiliations: Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California, United States of America, Mechanical and Aerospace Engineering Department, University of California Los Angeles, Los Angeles, California, United States of America

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  • Jiaying Feng,

    Affiliation: Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California, United States of America

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  • Xudong Li,

    Affiliation: Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California, United States of America

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  • Chia Wei Liao,

    Affiliation: Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California, United States of America

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  • Chih-Ming Ho,

    Affiliation: Mechanical and Aerospace Engineering Department, University of California Los Angeles, Los Angeles, California, United States of America

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  • Jeff S. Shamma,

    Affiliation: School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, Georgia, United States of America

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  • Ren Sun mail

    rsun@mednet.ucla.edu

    Affiliation: Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California, United States of America

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  • Published: June 28, 2011
  • DOI: 10.1371/journal.pone.0020998

About the Authors

Fuqu Yu, Ibrahim Al-Shyoukh, Jiaying Feng, Xudong Li, Chia Wei Liao, Ren Sun
Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California, United States of America
Ibrahim Al-Shyoukh, Chih-Ming Ho
Mechanical and Aerospace Engineering Department, University of California Los Angeles, Los Angeles, California, United States of America
Jeff S. Shamma
School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, Georgia, United States of America

Corresponding Author

Email: rsun@mednet.ucla.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: FY IAS CMH JSS RS. Performed the experiments: FY JF XL CWL. Analyzed the data: IAS FY RS. Contributed reagents/materials/analysis tools: FY IAS JF XL RS. Wrote the paper: IAS FY RS. Introduced the idea to optimize drug combinations using a mathematical feedback algorithm: CHM.