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Research Article

Deletion of Insulin-Degrading Enzyme Elicits Antipodal, Age-Dependent Effects on Glucose and Insulin Tolerance

  • Samer O. Abdul-Hay,

    Affiliation: Department of Neuroscience, Mayo Clinic Florida, Jacksonville, Florida, United States of America

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  • Dongcheul Kang,

    Affiliation: Department of Neuroscience, Mayo Clinic Florida, Jacksonville, Florida, United States of America

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  • Melinda McBride,

    Affiliation: Department of Neuroscience, Mayo Clinic Florida, Jacksonville, Florida, United States of America

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  • Lilin Li,

    Affiliation: Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, Florida, United States of America

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  • Ji Zhao,

    Affiliation: Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, Florida, United States of America

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  • Malcolm A. Leissring mail

    Leissring@mayo.edu

    Affiliations: Department of Neuroscience, Mayo Clinic Florida, Jacksonville, Florida, United States of America, Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, Florida, United States of America

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  • Published: June 09, 2011
  • DOI: 10.1371/journal.pone.0020818

About the Authors

Samer O. Abdul-Hay, Dongcheul Kang, Melinda McBride, Malcolm A. Leissring
Department of Neuroscience, Mayo Clinic Florida, Jacksonville, Florida, United States of America
Lilin Li, Ji Zhao, Malcolm A. Leissring
Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, Florida, United States of America

Corresponding Author

Email: Leissring@mayo.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MAL LL JZ. Performed the experiments: SOA-H DK MM LL JZ. Analyzed the data: SOA-H JZ MAL. Wrote the paper: SOA-H MAL.