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Research Article

Promoter Methylation in Head and Neck Squamous Cell Carcinoma Cell Lines Is Significantly Different than Methylation in Primary Tumors and Xenografts

  • Patrick T. Hennessey,

    Affiliation: Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America

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  • Michael F. Ochs,

    Affiliations: Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America, Division of Biostatistics and Bioinformatics, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America

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  • Wojciech W. Mydlarz,

    Affiliation: Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America

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  • Wayne Hsueh,

    Affiliation: Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America

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  • Leslie Cope,

    Affiliations: Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America, Division of Biostatistics and Bioinformatics, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America

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  • Wayne Yu,

    Affiliation: Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America

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  • Joseph A. Califano mail

    jcalifa@jhmi.edu

    Affiliations: Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America, Milton J. Dance Head and Neck Center, Greater Baltimore Medical Center, Baltimore, Maryland, United States of America

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  • Published: May 26, 2011
  • DOI: 10.1371/journal.pone.0020584

About the Authors

Patrick T. Hennessey, Wojciech W. Mydlarz, Joseph A. Califano
Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America
Michael F. Ochs, Leslie Cope
Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America
Michael F. Ochs, Leslie Cope
Division of Biostatistics and Bioinformatics, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America
Wayne Hsueh
Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
Wayne Yu
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America
Joseph A. Califano
Milton J. Dance Head and Neck Center, Greater Baltimore Medical Center, Baltimore, Maryland, United States of America

Corresponding Author

Email: jcalifa@jhmi.edu

Competing Interests

Dr. Califano is the Director of Research of the Milton J. Dance Head and Neck Endowment. The terms of this arrangement are being managed by the Johns Hopkins University in accordance with its conflict of interest policies.

Author Contributions

Conceived and designed the experiments: PTH MFO JAC. Performed the experiments: PTH WWM WH WY. Analyzed the data: PTH MFO WY. Contributed reagents/materials/analysis tools: PTH MFO LC JAC. Wrote the paper: PTH MFO.