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Research Article

Protective Effects of Positive Lysosomal Modulation in Alzheimer's Disease Transgenic Mouse Models

  • David Butler,

    Affiliations: Neurosciences Program, University of Connecticut, Storrs, Connecticut, United States of America, Department of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut, United States of America

    Current address: Center for Neurologic Disease, Harvard Institutes of Medicine, Boston, Massachusetts, United States of America

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  • Jeannie Hwang,

    Affiliations: Neurosciences Program, University of Connecticut, Storrs, Connecticut, United States of America, Department of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut, United States of America, William C. Friday Laboratory, Biotechnology Research and Training Center, University of North Carolina Pembroke, Pembroke, North Carolina, United States of America

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  • Candice Estick,

    Affiliations: Neurosciences Program, University of Connecticut, Storrs, Connecticut, United States of America, Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, United States of America

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  • Akiko Nishiyama,

    Affiliation: Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, United States of America

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  • Saranya Santhosh Kumar,

    Affiliations: Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, United States of America, Department of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut, United States of America

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  • Clive Baveghems,

    Affiliation: Department of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut, United States of America

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  • Hollie B. Young-Oxendine,

    Affiliation: William C. Friday Laboratory, Biotechnology Research and Training Center, University of North Carolina Pembroke, Pembroke, North Carolina, United States of America

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  • Meagan L. Wisniewski,

    Affiliation: William C. Friday Laboratory, Biotechnology Research and Training Center, University of North Carolina Pembroke, Pembroke, North Carolina, United States of America

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  • Ana Charalambides,

    Affiliations: Department of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut, United States of America, William C. Friday Laboratory, Biotechnology Research and Training Center, University of North Carolina Pembroke, Pembroke, North Carolina, United States of America

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  • Ben A. Bahr mail

    Bahr@uncp.edu

    Affiliations: Neurosciences Program, University of Connecticut, Storrs, Connecticut, United States of America, Department of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut, United States of America, William C. Friday Laboratory, Biotechnology Research and Training Center, University of North Carolina Pembroke, Pembroke, North Carolina, United States of America, Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, United States of America, Department of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut, United States of America

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  • Published: June 10, 2011
  • DOI: 10.1371/journal.pone.0020501

About the Authors

David Butler, Jeannie Hwang, Candice Estick, Ben A. Bahr
Neurosciences Program, University of Connecticut, Storrs, Connecticut, United States of America
David Butler, Jeannie Hwang, Clive Baveghems, Ana Charalambides, Ben A. Bahr
Department of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut, United States of America
Jeannie Hwang, Hollie B. Young-Oxendine, Meagan L. Wisniewski, Ana Charalambides, Ben A. Bahr
William C. Friday Laboratory, Biotechnology Research and Training Center, University of North Carolina Pembroke, Pembroke, North Carolina, United States of America
Candice Estick, Akiko Nishiyama, Saranya Santhosh Kumar, Ben A. Bahr
Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, United States of America
Saranya Santhosh Kumar, Ben A. Bahr
Department of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut, United States of America

Corresponding Author

Email: Bahr@uncp.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DB BAB. Performed the experiments: DB JH CE SSK CB HBY-O MLW AC BAB. Analyzed the data: DB JH CE AN SSK HBY-O MLW AC BAB. Contributed reagents/materials/analysis tools: AN BAB. Wrote the paper: DB JH BAB.