About the Authors
- Maxwell A. Kotlarchyk
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Contributed equally to this work with: Maxwell A. Kotlarchyk, Samir G. Shreim
Affiliation Department of Biomedical Engineering, University of California Irvine, Irvine, California, United States of America
- Samir G. Shreim
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Contributed equally to this work with: Maxwell A. Kotlarchyk, Samir G. Shreim
Affiliation Department of Biomedical Engineering, University of California Irvine, Irvine, California, United States of America
- Martha B. Alvarez-Elizondo
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Affiliations Department of Biomedical Engineering, University of California Irvine, Irvine, California, United States of America, Beckman Laser Institute and Medical Clinic, University of California Irvine, Irvine, California, United States of America
- Laura C. Estrada
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Affiliations Department of Biomedical Engineering, University of California Irvine, Irvine, California, United States of America, Laboratory for Fluorescence Dynamics, University of California Irvine, Irvine, California, United States of America
- Rahul Singh
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Affiliation Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, United States of America
- Lorenzo Valdevit
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Affiliation Department of Mechanical and Aerospace Engineering and Department of Chemical Engineering and Materials Science, University of California Irvine, Irvine, California, United States of America
- Ekaterina Kniazeva
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Affiliation Department of Biomedical Engineering, University of California Irvine, Irvine, California, United States of America
- Enrico Gratton
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Affiliations Department of Biomedical Engineering, University of California Irvine, Irvine, California, United States of America, Laboratory for Fluorescence Dynamics, University of California Irvine, Irvine, California, United States of America
- Andrew J. Putnam
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Affiliations Department of Biomedical Engineering, University of California Irvine, Irvine, California, United States of America, Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, United States of America
- Elliot L. Botvinick
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* E-mail: elliot.botvinick@uci.edu
Affiliations Department of Biomedical Engineering, University of California Irvine, Irvine, California, United States of America, Beckman Laser Institute and Medical Clinic, University of California Irvine, Irvine, California, United States of America, Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California Irvine, Irvine, California, United States of America
Competing Interests
The authors have declared that no competing interests exist.
Author Contributions
Assembled microrheology system, performed all microrheology and imaging, assisted with the shear gradient device design, and wrote this paper: MAK. Designed and machined the shear gradient device: SGS. Assisted with assembly of the microrheology system and analysis of acquired signals: MBA. Enabled multiphoton orbital particle tracking of fibrin fibers: LCE. Performed all macrorheology experiments: RS. Did the FEA for the device: LV. Performed cell culture for initial cell-based microrheology experiments: EK. Conceived the particle tracking experiments: EG. Conceived the shear gradient device: ELB. Conceived and supervised the microrheology experiments and edited this paper: AJP ELB.