About the Authors

Manfred G. Grabherr

Contributed equally to this work with: Manfred G. Grabherr, Jens Pontiller

Affiliation Broad Institute, Cambridge, Massachusetts, United States of America

Jens Pontiller

Contributed equally to this work with: Manfred G. Grabherr, Jens Pontiller

Affiliation Department of Biotechnology, University of Natural Resources and Life Sciences, Vienna, Austria

Evan Mauceli

evan@broadinstitute.org

Affiliation Broad Institute, Cambridge, Massachusetts, United States of America

Wolfgang Ernst

Affiliation Department of Biotechnology, University of Natural Resources and Life Sciences, Vienna, Austria

Martina Baumann

Affiliation Department of Biotechnology, University of Natural Resources and Life Sciences, Vienna, Austria

Tara Biagi

Affiliation Broad Institute, Cambridge, Massachusetts, United States of America

Ross Swofford

Affiliation Broad Institute, Cambridge, Massachusetts, United States of America

Pamela Russell

Affiliation Broad Institute, Cambridge, Massachusetts, United States of America

Michael C. Zody

Affiliations Broad Institute, Cambridge, Massachusetts, United States of America, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden

Federica Di Palma

Affiliation Broad Institute, Cambridge, Massachusetts, United States of America

Kerstin Lindblad-Toh

Affiliations Broad Institute, Cambridge, Massachusetts, United States of America, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden

Reingard M. Grabherr

Affiliation Department of Biotechnology, University of Natural Resources and Life Sciences, Vienna, Austria

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MGG RMG WE JP EM PR MB MCZ KL-T FDP. Performed the experiments: JP MB TB RS. Analyzed the data: EM PR MCZ MGG. Contributed reagents/materials/analysis tools: EM PR MCZ MGG. Wrote the paper: MGG RMG JP EM WE MCZ FDP KL-T. Had the idea: MGG RMG. Designed laboratory experiments: JP WE RMG. Performed all in vitro experiments: JP. Designed and conducted the protein-DNA binding experiments: MB. Constructed the RNA library: TB RS. Conceived of and implemented the computational analyses: EM PR MCZ MGG. Advised on experimental design, computational analyses, and interpretation: KL-T FDP.