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Research Article

Degradation of the Disease-Associated Prion Protein by a Serine Protease from Lichens

  • Christopher J. Johnson mail,

    cjjohnson@usgs.gov

    Affiliations: Prion Research Laboratory, United States Geological Survey National Wildlife Health Center, Madison, Wisconsin, United States of America, Department of Veterinary Molecular Biology, Montana State University, Bozeman, Montana, United States of America

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  • James P. Bennett,

    Affiliations: Prion Research Laboratory, United States Geological Survey National Wildlife Health Center, Madison, Wisconsin, United States of America, Institute for Environmental Studies, University of Wisconsin, Madison, Wisconsin, United States of America

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  • Steven M. Biro,

    Affiliations: Prion Research Laboratory, United States Geological Survey National Wildlife Health Center, Madison, Wisconsin, United States of America, Department of Bacteriology, University of Wisconsin, Madison, Wisconsin, United States of America

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  • Juan Camilo Duque-Velasquez,

    Affiliation: Grupo de Investigación CENTAURO, Facultad de Ciencias Agrarias, Universidad de Antioquia, Medellín, Antioquia, Colombia

    Current address: Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada

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  • Cynthia M. Rodriguez,

    Affiliations: Prion Research Laboratory, United States Geological Survey National Wildlife Health Center, Madison, Wisconsin, United States of America, Department of Bacteriology, University of Wisconsin, Madison, Wisconsin, United States of America

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  • Richard A. Bessen,

    Affiliation: Department of Veterinary Molecular Biology, Montana State University, Bozeman, Montana, United States of America

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  • Tonie E. Rocke

    Affiliation: Prion Research Laboratory, United States Geological Survey National Wildlife Health Center, Madison, Wisconsin, United States of America

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  • Published: May 11, 2011
  • DOI: 10.1371/journal.pone.0019836

About the Authors

Christopher J. Johnson, James P. Bennett, Steven M. Biro, Cynthia M. Rodriguez, Tonie E. Rocke
Prion Research Laboratory, United States Geological Survey National Wildlife Health Center, Madison, Wisconsin, United States of America
Christopher J. Johnson, Richard A. Bessen
Department of Veterinary Molecular Biology, Montana State University, Bozeman, Montana, United States of America
James P. Bennett
Institute for Environmental Studies, University of Wisconsin, Madison, Wisconsin, United States of America
Steven M. Biro, Cynthia M. Rodriguez
Department of Bacteriology, University of Wisconsin, Madison, Wisconsin, United States of America
Juan Camilo Duque-Velasquez
Grupo de Investigación CENTAURO, Facultad de Ciencias Agrarias, Universidad de Antioquia, Medellín, Antioquia, Colombia

Corresponding Author

Email: cjjohnson@usgs.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CJJ JPB SMB JCDV CMR RAB TER. Performed the experiments: CJJ SMB JCDV CMR. Analyzed the data: CJJ JPB SMB JCDV CMR RAB TER. Contributed reagents/materials/analysis tools: CJJ JPB RAB TER. Wrote the paper: CJJ JPB SMB JCDV CMR RAB TER.