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Research Article

Mitostatin Is Down-Regulated in Human Prostate Cancer and Suppresses the Invasive Phenotype of Prostate Cancer Cells

  • Matteo Fassan,

    Affiliations: Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America, Department of Diagnostic Medicine and Special Therapies, University of Padova, Padova, Italy

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  • Domenico D'Arca,

    Affiliation: Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • Juraj Letko,

    Affiliation: Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • Andrea Vecchione,

    Affiliations: Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America, Division of Pathology, II Faculty of Medicine, University “La Sapienza,” Ospedale Sant'Andrea, Rome, Italy

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  • Marina P. Gardiman,

    Affiliation: Department of Diagnostic Medicine and Special Therapies, University of Padova, Padova, Italy

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  • Peter McCue,

    Affiliation: Department of Pathology, Anatomy and Cell Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • Bernadette Wildemore,

    Affiliation: Department of Pathology, Anatomy and Cell Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • Massimo Rugge,

    Affiliation: Department of Diagnostic Medicine and Special Therapies, University of Padova, Padova, Italy

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  • Dolores Shupp-Byrne,

    Affiliation: Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • Leonard G. Gomella,

    Affiliation: Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • Andrea Morrione,

    Affiliation: Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • Renato V. Iozzo,

    Affiliation: Department of Pathology, Anatomy and Cell Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • Raffaele Baffa mail

    R_Baffa@mail.jci.tju.edu

    Affiliation: Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

    Current address: Global Oncology Division, Sanofi-Aventis, Cambridge, Massachusetts, United States of America

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  • Published: May 06, 2011
  • DOI: 10.1371/journal.pone.0019771

About the Authors

Matteo Fassan, Domenico D'Arca, Juraj Letko, Andrea Vecchione, Dolores Shupp-Byrne, Leonard G. Gomella, Andrea Morrione, Raffaele Baffa
Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
Peter McCue, Bernadette Wildemore, Renato V. Iozzo
Department of Pathology, Anatomy and Cell Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
Matteo Fassan, Marina P. Gardiman, Massimo Rugge
Department of Diagnostic Medicine and Special Therapies, University of Padova, Padova, Italy
Andrea Vecchione
Division of Pathology, II Faculty of Medicine, University “La Sapienza,” Ospedale Sant'Andrea, Rome, Italy

Corresponding Author

Email: R_Baffa@mail.jci.tju.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MF AM RVI RB. Performed the experiments: MF DD JL AV BW. Analyzed the data: MF DS-B LGG AM RVI RB. Contributed reagents/materials/analysis tools: MPG PM MR LGG AM RB. Wrote the paper: MF AM RB.