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Research Article

Synaptically-Competent Neurons Derived from Canine Embryonic Stem Cells by Lineage Selection with EGF and Noggin

  • Jared T. Wilcox mail,

    jared.wilcox@utoronto.ca (JTW); dean.betts@schulich.uwo.ca (DHB)

    Affiliations: Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada, Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada

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  • Jonathan K. Y. Lai,

    Affiliation: Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada

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  • Esther Semple,

    Affiliation: Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada

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  • Brigitte A. Brisson,

    Affiliation: Department of Clinical Studies, Ontario Veterinary College, Guelph, Ontario, Canada

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  • Cathy Gartley,

    Affiliation: Department of Population Medicine, Ontario Veterinary College, Guelph, Ontario, Canada

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  • John N. Armstrong,

    Affiliation: Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada

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  • Dean H. Betts mail

    jared.wilcox@utoronto.ca (JTW); dean.betts@schulich.uwo.ca (DHB)

    Affiliation: Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada

    Current address: Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada

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  • Published: May 17, 2011
  • DOI: 10.1371/journal.pone.0019768

About the Authors

Jared T. Wilcox, Jonathan K. Y. Lai, Esther Semple, John N. Armstrong, Dean H. Betts
Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada
Jared T. Wilcox
Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada
Brigitte A. Brisson
Department of Clinical Studies, Ontario Veterinary College, Guelph, Ontario, Canada
Cathy Gartley
Department of Population Medicine, Ontario Veterinary College, Guelph, Ontario, Canada

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JTW JNA DHB. Performed the experiments: JTW JKYL ES JNA. Analyzed the data: JTW JKYL JNA. Contributed reagents/materials/analysis tools: BAB CG. Wrote the paper: JTW.