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Research Article

Transient Gastric Irritation in the Neonatal Rats Leads to Changes in Hypothalamic CRF Expression, Depression- and Anxiety-Like Behavior as Adults

  • Liansheng Liu,

    Affiliation: Division of Gastroenterology and Hepatology, Stanford University Medical Center, Stanford, California, United States of America

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  • Qian Li,

    Affiliation: Department of Pharmacology and Toxicology, University of Kansas, Kansas City, Kansas, United States of America

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  • Robert Sapolsky,

    Affiliation: Department of Biology, School of Humanities and Sciences, Stanford University, Stanford, California, United States of America

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  • Min Liao,

    Affiliation: Department of Surgery, University of California San Francisco, San Francisco, United States of America

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  • Kshama Mehta,

    Affiliation: Division of Gastroenterology and Hepatology, Stanford University Medical Center, Stanford, California, United States of America

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  • Aditi Bhargava,

    Affiliation: Department of Surgery, University of California San Francisco, San Francisco, United States of America

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  • Pankaj J. Pasricha mail

    Pasricha@stanford.edu

    Affiliation: Division of Gastroenterology and Hepatology, Stanford University Medical Center, Stanford, California, United States of America

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  • Published: May 12, 2011
  • DOI: 10.1371/journal.pone.0019498

About the Authors

Liansheng Liu, Kshama Mehta, Pankaj J. Pasricha
Division of Gastroenterology and Hepatology, Stanford University Medical Center, Stanford, California, United States of America
Qian Li
Department of Pharmacology and Toxicology, University of Kansas, Kansas City, Kansas, United States of America
Robert Sapolsky
Department of Biology, School of Humanities and Sciences, Stanford University, Stanford, California, United States of America
Min Liao, Aditi Bhargava
Department of Surgery, University of California San Francisco, San Francisco, United States of America

Corresponding Author

Email: Pasricha@stanford.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PJP. Performed the experiments: LL QL KM AB ML. Analyzed the data: PJP AB LL QL RS. Contributed reagents/materials/analysis tools: PJP AB QL. Wrote the paper: PJP LL QL AB RS.