About the Authors

Ting-lei Gu

tgu@cellsignal.com (T-lG); rpolakiewicz@cellsignal.com (RDP)

Affiliation Cell Signaling Technology, Inc., Danvers, Massachusetts, United States of America

Julie Nardone

Affiliation Cell Signaling Technology, Inc., Danvers, Massachusetts, United States of America

Yi Wang

Affiliation Cell Signaling Technology, Inc., Danvers, Massachusetts, United States of America

Marc Loriaux

Affiliation Department of Pathology, Oregon Health & Science University, Portland, Oregon, United States of America

Judit Villén

Affiliation Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America

Sean Beausoleil

Affiliation Cell Signaling Technology, Inc., Danvers, Massachusetts, United States of America

Meghan Tucker

Affiliation Cell Signaling Technology, Inc., Danvers, Massachusetts, United States of America

Jon Kornhauser

Affiliation Cell Signaling Technology, Inc., Danvers, Massachusetts, United States of America

Jianmin Ren

Affiliation Cell Signaling Technology, Inc., Danvers, Massachusetts, United States of America

Joan MacNeill

Affiliation Cell Signaling Technology, Inc., Danvers, Massachusetts, United States of America

Steven P. Gygi

Affiliation Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America

Brian J. Druker

Affiliations Department of Hematology and Medical Oncology, Oregon Health & Science University, Portland, Oregon, United States of America, Howard Hughes Medical Institute, Portland, Oregon, United States of America

Michael C. Heinrich

Affiliations Department of Hematology and Medical Oncology, Oregon Health & Science University, Portland, Oregon, United States of America, Portland VA Medical Center, Portland, Oregon, United States of America

John Rush

Affiliation Cell Signaling Technology, Inc., Danvers, Massachusetts, United States of America

Roberto D. Polakiewicz

tgu@cellsignal.com (T-lG); rpolakiewicz@cellsignal.com (RDP)

Affiliation Cell Signaling Technology, Inc., Danvers, Massachusetts, United States of America

Competing Interests

T.L.G., J.N., Y.W., S.B., M.T., J.K., J.M.R., J.M., J.R., and R.D.P. are employees of Cell Signaling Technology, Inc. There are no patents, products in development or marketed products to declare. This does not alter our adherence to all the PLoS ONE policies on sharing data and materials. M.L., J.V., S.P.G., B.J.D. and M.C.H. have no conflict of interest to declare.

Author Contributions

Conceived and designed the experiments: T-lG RDP. Performed the experiments: T-lG JN YW SB MT JK JMR JM JR. Analyzed the data: JN YW. Contributed reagents/materials/analysis tools: ML JV SPG BJD MCH. Wrote the paper: T-lG RDP.