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Research Article

MiR-21 Induced Angiogenesis through AKT and ERK Activation and HIF-1α Expression

  • Ling-Zhi Liu,

    Affiliations: Lab of Reproductive Medicine, Department of Pathology, Cancer Center, Nanjing Medical University, Nanjing, Jiangsu, China, Department of Pathology, Anatomy and Cell Biology, and Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • Chongyong Li,

    Affiliation: Lab of Reproductive Medicine, Department of Pathology, Cancer Center, Nanjing Medical University, Nanjing, Jiangsu, China

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  • Qi Chen,

    Affiliation: Lab of Reproductive Medicine, Department of Pathology, Cancer Center, Nanjing Medical University, Nanjing, Jiangsu, China

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  • Yi Jing,

    Affiliation: Department of Pathology, Anatomy and Cell Biology, and Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • Richard Carpenter,

    Affiliation: Department of Pathology, Anatomy and Cell Biology, and Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • Yue Jiang,

    Affiliation: Department of Pathology, Anatomy and Cell Biology, and Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • Hsiang-Fu Kung,

    Affiliation: Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China

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  • Lihui Lai,

    Affiliation: Institute of Molecular and Chemical Biology, East China Normal University, Shanghai, China

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  • Bing-Hua Jiang mail

    binghjiang@yahoo.com

    Affiliations: Lab of Reproductive Medicine, Department of Pathology, Cancer Center, Nanjing Medical University, Nanjing, Jiangsu, China, Department of Pathology, Anatomy and Cell Biology, and Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • Published: April 22, 2011
  • DOI: 10.1371/journal.pone.0019139

About the Authors

Ling-Zhi Liu, Chongyong Li, Qi Chen, Bing-Hua Jiang
Lab of Reproductive Medicine, Department of Pathology, Cancer Center, Nanjing Medical University, Nanjing, Jiangsu, China
Ling-Zhi Liu, Yi Jing, Richard Carpenter, Yue Jiang, Bing-Hua Jiang
Department of Pathology, Anatomy and Cell Biology, and Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
Hsiang-Fu Kung
Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
Lihui Lai
Institute of Molecular and Chemical Biology, East China Normal University, Shanghai, China

Corresponding Author

Email: binghjiang@yahoo.com

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BHJ LZL. Performed the experiments: LZL CL Y. Jing Y. Jiang RC LL. Analyzed the data: LZL QC HFK. Contributed reagents/materials/analysis tools: HFK. Wrote the paper: LZL BHJ.