About the Authors

Ying Sun

Affiliations The Division of Human Genetics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America, The Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America

Huimin Ran

Affiliations The Division of Human Genetics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America, The Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America

Benjamin Liou

Affiliations The Division of Human Genetics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America, The Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America

Brian Quinn

Affiliations The Division of Human Genetics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America, The Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America

Matt Zamzow

Affiliations The Division of Human Genetics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America, The Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America

Wujuan Zhang

Affiliations The Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America, The Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America

Jacek Bielawski

Affiliation The Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, United States of America

Kazuyuki Kitatani

Affiliations The Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, United States of America, The Department of Clinical Laboratory, Tottori University Hospital, Tottori University, Yonago, Japan

Kenneth D. R. Setchell

Affiliations The Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America, The Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America

Yusuf A. Hannun

Affiliation The Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, United States of America

Gregory A. Grabowski

Greg.Grabowski@cchmc.org

Affiliations The Division of Human Genetics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America, The Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: YS GAG. Performed the experiments: HR BL BQ MZ WZ JB KK YS. Analyzed the data: YS WZ KK KDRS YAH GAG. Contributed reagents/materials/analysis tools: KDRS YAH. Wrote the paper: YS KDRS YAH GAG.