About the Authors

Rebecca Craig-Schapiro

Affiliation Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, United States of America

Max Kuhn

Affiliations Neuroscience Research Unit, Pfizer Global Research and Development, Groton, Connecticut, United States of America, Neuroscience Research Unit, Pfizer Global Research and Development, St. Louis, Missouri, United States of America

Chengjie Xiong

Affiliations The Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, Missouri, United States of America, Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, United States of America

Eve H. Pickering

Affiliations Neuroscience Research Unit, Pfizer Global Research and Development, Groton, Connecticut, United States of America, Neuroscience Research Unit, Pfizer Global Research and Development, St. Louis, Missouri, United States of America

Jingxia Liu

Affiliation Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, United States of America

Thomas P. Misko

Affiliations Neuroscience Research Unit, Pfizer Global Research and Development, Groton, Connecticut, United States of America, Neuroscience Research Unit, Pfizer Global Research and Development, St. Louis, Missouri, United States of America

Richard J. Perrin

Affiliations The Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, Missouri, United States of America, Division of Neuropathology, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America

Kelly R. Bales

Affiliations Neuroscience Research Unit, Pfizer Global Research and Development, Groton, Connecticut, United States of America, Neuroscience Research Unit, Pfizer Global Research and Development, St. Louis, Missouri, United States of America

Holly Soares

Affiliations Neuroscience Research Unit, Pfizer Global Research and Development, Groton, Connecticut, United States of America, Neuroscience Research Unit, Pfizer Global Research and Development, St. Louis, Missouri, United States of America

Anne M. Fagan

Affiliations Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, United States of America, The Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, Missouri, United States of America, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, Missouri, United States of America

David M. Holtzman

holtzman@neuro.wustl.edu

Affiliations Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, United States of America, The Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, Missouri, United States of America, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, Missouri, United States of America

Competing Interests

The authors have read the journal's policy and have the following conflicts: Max Kuhn, Eve H. Pickering, Kelly R. Bales are paid employees of Pfizer. They have no other competing interests relevant to the data in this manuscript. Thomas P. Misko and Holly Soares were paid employees of Pfizer during the course of this study. They have no other competing interests relevant to the data in this manuscript. David M. Holtzman co-founded the company C2N Diagnostics and has ownership interests. He serves on the Scientific Advisory Boards of En Vivo and Satori. He has no other competing interests relevant to the data in this manuscript. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials. Rebecca Craig-Schapiro, Chengjie Xiong, Jingxia Liu, Richard J. Perrin, and Anne M. Fagan have no competing interests to declare.

Author Contributions

Conceived and designed the experiments: RC-S MK CX EHP TPM RJP KRB HS AMF DMH. Performed the experiments: RC-S MK CX TPM. Analyzed the data: RC-S MK CX EHP JL KRB HS DMH. Contributed reagents/materials/analysis tools: RC-S MK CX EHP TPM AMF DMH. Wrote the paper: RC-S MK TPM RJP HS DMH.