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Research Article

Inhibition of Fried Meat-Induced Colorectal DNA Damage and Altered Systemic Genotoxicity in Humans by Crucifera, Chlorophyllin, and Yogurt

  • Daniel T. Shaughnessy,

    Affiliation: Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina, United States of America

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  • Lisa M. Gangarosa,

    Affiliation: Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, United States of America

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  • Barbara Schliebe,

    Affiliation: Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, United States of America

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  • David M. Umbach,

    Affiliation: Biostatistics Branch, National Institute of Environmental Health Sciences, National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina, United States of America

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  • Zongli Xu,

    Affiliation: Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina, United States of America

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  • Beth MacIntosh,

    Affiliation: Clinical and Translational Research Center, University of North Carolina, Chapel Hill, North Carolina, United States of America

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  • Mark G. Knize,

    Affiliation: Chemistry, Materials, and Life Sciences Division, Lawrence Livermore National Laboratory, Livermore, California, United States of America

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  • Peggy P. Matthews,

    Affiliation: National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America

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  • Adam E. Swank,

    Affiliation: National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America

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  • Robert S. Sandler,

    Affiliation: Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, United States of America

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  • David M. DeMarini,

    Affiliation: National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America

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  • Jack A. Taylor mail

    taylor@niehs.nih.gov

    Affiliations: Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina, United States of America, Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina, United States of America

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  • Published: April 25, 2011
  • DOI: 10.1371/journal.pone.0018707

About the Authors

Daniel T. Shaughnessy, Jack A. Taylor
Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina, United States of America
Lisa M. Gangarosa, Barbara Schliebe, Robert S. Sandler
Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, United States of America
David M. Umbach
Biostatistics Branch, National Institute of Environmental Health Sciences, National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina, United States of America
Zongli Xu, Jack A. Taylor
Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina, United States of America
Beth MacIntosh
Clinical and Translational Research Center, University of North Carolina, Chapel Hill, North Carolina, United States of America
Mark G. Knize
Chemistry, Materials, and Life Sciences Division, Lawrence Livermore National Laboratory, Livermore, California, United States of America
Peggy P. Matthews, Adam E. Swank, David M. DeMarini
National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America

Corresponding Author

Email: taylor@niehs.nih.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DS RS JT DD DU. Performed the experiments: DS AS DD PM MK. Analyzed the data: DS JT DU ZX DD. Contributed reagents/materials/analysis tools: DS JT DD MK. Wrote the paper: DS DD JT DU. Study coordinator: BS. Research dietician: BM. Clinical physician on the study: LG.