About the Authors

Suzy A. A. Comhair

comhais@ccf.org (SAAC); erzurus@ccf.org (SCE)

Affiliation Departments of Pathobiology, Cleveland Clinic, Cleveland, Ohio, United States of America

Benjamin M. Gaston

Affiliation Department of Pediatrics, University of Virginia, Charlottesville, Virginia, United States of America

Kristin S. Ricci

Affiliation Departments of Pathobiology, Cleveland Clinic, Cleveland, Ohio, United States of America

Jeffrey Hammel

Affiliation Departments of Pathobiology, Cleveland Clinic, Cleveland, Ohio, United States of America

Raed A. Dweik

Affiliations Departments of Pathobiology, Cleveland Clinic, Cleveland, Ohio, United States of America, Respiratory Institute, Cleveland Clinic, Cleveland, Ohio, United States of America

W. Gerald Teague

Affiliation Department of Pediatrics, University of Virginia, Charlottesville, Virginia, United States of America

Deborah Meyers

Affiliation Pulmonary, Critical Care, Allergy and Immunologic Diseases, Wake Forest University, Winston-Salem, North Carolina, United States of America

Elizabeth J. Ampleford

Affiliation Pulmonary, Critical Care, Allergy and Immunologic Diseases, Wake Forest University, Winston-Salem, North Carolina, United States of America

Eugene R. Bleecker

Affiliation Pulmonary, Critical Care, Allergy and Immunologic Diseases, Wake Forest University, Winston-Salem, North Carolina, United States of America

William W. Busse

Affiliation Department of Internal Medicine, University of Wisconsin, Madison, Wisconsin, United State of America

William J. Calhoun

Affiliation Department of Internal Medicine, University of Texas Medical Branch at Galveston, Galveston, Texas, United States of America

Mario Castro

Affiliation Internal Medicine/Pulmonary and Critical Care Medicine, Washington University, St Louis, Missouri, United States of America

Kian Fan Chung

Affiliation National Heart and Lung Institute, Imperial College School of Medicine, London, United Kingdom

Douglas Curran-Everett

Affiliation Division of Biostatistics, National Jewish Center, Denver, Colorado, United States of America

Elliot Israel

Affiliation Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

W. Nizar Jarjour

Affiliation Department of Internal Medicine, University of Wisconsin, Madison, Wisconsin, United State of America

Wendy Moore

Affiliation Pulmonary, Critical Care, Allergy and Immunologic Diseases, Wake Forest University, Winston-Salem, North Carolina, United States of America

Stephen P. Peters

Affiliation Pulmonary, Critical Care, Allergy and Immunologic Diseases, Wake Forest University, Winston-Salem, North Carolina, United States of America

Sally Wenzel

Affiliation Asthma Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Stanley L. Hazen

Affiliation Department of Cell Biology and Center for Cardiovascular Diagnostics and Prevention, Cleveland Clinic, Cleveland, Ohio, United States of America

Serpil C. Erzurum

comhais@ccf.org (SAAC); erzurus@ccf.org (SCE)

Affiliations Departments of Pathobiology, Cleveland Clinic, Cleveland, Ohio, United States of America, Respiratory Institute, Cleveland Clinic, Cleveland, Ohio, United States of America

for the National Heart Lung Blood Institute Severe Asthma Research Program (SARP)

¤ For information on the National Heart Lung Blood Institute Severe Asthma Research Program (SARP) please see the Acknowledgments section.

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SAAC BMG RAD SLH SCE. Performed the experiments: SAAC KSR. Analyzed the data: SAAC BMG JH SLH EJA SCE. Contributed reagents/materials/analysis tools: WGT ERB WWB WJC MC KFC EI WNJ WM SPP SW DM DC-E. Wrote the paper: SAAC BMG SCE.