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Research Article

NCI60 Cancer Cell Line Panel Data and RNAi Analysis Help Identify EAF2 as a Modulator of Simvastatin and Lovastatin Response in HCT-116 Cells

  • Sevtap Savas,

    Affiliations: Fred A. Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada, Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada

    Current address: Discipline of Genetics, Faculty of Medicine, Memorial University, St. John's, Canada

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  • David O. Azorsa mail,

    dazorsa@tgen.org

    Affiliations: The Pharmaceutical Genomics Division, Translational Genomics Research Institute (TGen), Scottsdale, Arizona, United States of America, The Clinical Translational Research Division, Translational Genomics Research Institute (TGen), Scottsdale, Arizona, United States of America

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  • Hamdi Jarjanazi,

    Affiliations: Fred A. Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada, Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada

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  • Irada Ibrahim-Zada,

    Affiliations: Fred A. Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada, Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada

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  • Irma M. Gonzales,

    Affiliations: The Pharmaceutical Genomics Division, Translational Genomics Research Institute (TGen), Scottsdale, Arizona, United States of America, The Clinical Translational Research Division, Translational Genomics Research Institute (TGen), Scottsdale, Arizona, United States of America

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  • Shilpi Arora,

    Affiliation: The Pharmaceutical Genomics Division, Translational Genomics Research Institute (TGen), Scottsdale, Arizona, United States of America

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  • Meredith C. Henderson,

    Affiliations: The Pharmaceutical Genomics Division, Translational Genomics Research Institute (TGen), Scottsdale, Arizona, United States of America, The Clinical Translational Research Division, Translational Genomics Research Institute (TGen), Scottsdale, Arizona, United States of America

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  • Yun Hee Choi,

    Affiliation: Prosserman Centre for Health Research, Mount Sinai Hospital, Toronto, Canada

    Current address: Department of Epidemiology and Biostatistics, The University of Western Ontario, London, Canada

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  • Laurent Briollais,

    Affiliation: Prosserman Centre for Health Research, Mount Sinai Hospital, Toronto, Canada

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  • Hilmi Ozcelik,

    Affiliations: Fred A. Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada, Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada

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  • Sukru Tuzmen

    Affiliation: The Pharmaceutical Genomics Division, Translational Genomics Research Institute (TGen), Scottsdale, Arizona, United States of America

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  • Published: April 04, 2011
  • DOI: 10.1371/journal.pone.0018306

About the Authors

Sevtap Savas, Hamdi Jarjanazi, Irada Ibrahim-Zada, Hilmi Ozcelik
Fred A. Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
Sevtap Savas, Hamdi Jarjanazi, Irada Ibrahim-Zada, Hilmi Ozcelik
Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada
Sevtap Savas, Hamdi Jarjanazi, Irada Ibrahim-Zada, Hilmi Ozcelik
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada
David O. Azorsa, Irma M. Gonzales, Shilpi Arora, Meredith C. Henderson, Sukru Tuzmen
The Pharmaceutical Genomics Division, Translational Genomics Research Institute (TGen), Scottsdale, Arizona, United States of America
David O. Azorsa, Irma M. Gonzales, Meredith C. Henderson
The Clinical Translational Research Division, Translational Genomics Research Institute (TGen), Scottsdale, Arizona, United States of America
Yun Hee Choi, Laurent Briollais
Prosserman Centre for Health Research, Mount Sinai Hospital, Toronto, Canada

Corresponding Author

Email: dazorsa@tgen.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SS DOA HJ II LB HO ST. Performed the experiments: SS HJ II IMG SA MCH YHC. Analyzed the data: SS DOA HJ II YHC LB ST. Wrote the paper: SS DOA HJ II LB YHC SA ST.