Point Mutations in Helicobacter pylori's fur Regulatory Gene that Alter Resistance to Metronidazole, a Prodrug Activated by Chemical Reduction

Sung Sook Choi; Peter T. Chivers; Douglas E. Berg

doi:10.1371/journal.pone.0018236

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Open Access

Peer-reviewed

Research Article

Point Mutations in Helicobacter pylori's fur Regulatory Gene that Alter Resistance to Metronidazole, a Prodrug Activated by Chemical Reduction

Sung Sook Choi,

Current address: College of Pharmacy, Sahmyook University, Seoul, South Korea

Affiliation Department of Molecular Microbiology, Washington University Medical School, St Louis, Missouri, United States of America
⨯
Peter T. Chivers,

Affiliation Department of Biochemistry and Molecular Biophysics, Washington University Medical School, St Louis, Missouri, United States of America
⨯
Douglas E. Berg

* E-mail: berg@borcim.wustl.edu

Affiliation Department of Molecular Microbiology, Washington University Medical School, St Louis, Missouri, United States of America
⨯

Point Mutations in Helicobacter pylori's fur Regulatory Gene that Alter Resistance to Metronidazole, a Prodrug Activated by Chemical Reduction

Sung Sook Choi,
Peter T. Chivers,
Douglas E. Berg

Published: March 25, 2011
https://doi.org/10.1371/journal.pone.0018236

About the Authors

Sung Sook Choi

Current address: College of Pharmacy, Sahmyook University, Seoul, South Korea

Affiliation Department of Molecular Microbiology, Washington University Medical School, St Louis, Missouri, United States of America

Peter T. Chivers

Affiliation Department of Biochemistry and Molecular Biophysics, Washington University Medical School, St Louis, Missouri, United States of America

Douglas E. Berg

* E-mail: berg@borcim.wustl.edu

Affiliation Department of Molecular Microbiology, Washington University Medical School, St Louis, Missouri, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SSC PTC DEB. Performed the experiments: SSC. Analyzed the data: SSC PTC DEB. Contributed reagents/materials/analysis tools: SSC PTC DEB. Wrote the paper: SSC PTC DEB.

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Regulator genes
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Helicobacter pylori
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Nonsense mutation
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Point mutation
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DNA-binding proteins
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Frameshift mutation
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Mutation
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Polymerase chain reaction
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