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Research Article

Systems-Scale Analysis Reveals Pathways Involved in Cellular Response to Methamphetamine

  • Lijie Sun,

    Affiliations: Department of Entomology, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America, Synthetic Biology & Bioenergy, J. Craig Venter Institute, San Diego, California, United States of America, Department of Entomology, Purdue University, West Lafayette, Indiana, United States of America

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  • Hong-Mei Li,

    Affiliation: Department of Entomology, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America

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  • Manfredo J. Seufferheld,

    Affiliation: Department of Crop Sciences, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America

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  • Kent R. Walters Jr.,

    Affiliation: Department of Entomology, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America

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  • Venu M. Margam,

    Affiliation: Department of Entomology, Purdue University, West Lafayette, Indiana, United States of America

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  • Amber Jannasch,

    Affiliation: Metabolomics Profiling Facility at Bindley Bioscience Center, Purdue University, West Lafayette, Indiana, United States of America

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  • Naomi Diaz,

    Affiliation: Metabolomics Profiling Facility at Bindley Bioscience Center, Purdue University, West Lafayette, Indiana, United States of America

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  • Catherine P. Riley,

    Affiliation: Metabolomics Profiling Facility at Bindley Bioscience Center, Purdue University, West Lafayette, Indiana, United States of America

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  • Weilin Sun,

    Affiliation: Department of Entomology, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America

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  • Yueh-Feng Li,

    Affiliations: Department of Entomology, Purdue University, West Lafayette, Indiana, United States of America, Chung Hwa College of Medical Technology, Jen-Te Hsiang, Tainan, Taiwan

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  • William M. Muir,

    Affiliation: Department of Animal Sciences, Purdue University, West Lafayette, Indiana, United States of America

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  • Jun Xie,

    Affiliation: Department of Statistics, Purdue University, West Lafayette, Indiana, United States of America

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  • Jing Wu,

    Affiliation: Department of Statistics, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America

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  • Fan Zhang,

    Affiliation: School of Informatics, Indiana University, Indianapolis, Indiana, United States of America

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  • Jake Y. Chen,

    Affiliation: School of Informatics, Indiana University, Indianapolis, Indiana, United States of America

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  • Eric L. Barker,

    Affiliation: Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana, United States of America

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  • Jiri Adamec,

    Affiliation: Department of Biochemistry, University of Nebraska, Lincoln, Nebraska, United States of America

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  • Barry R. Pittendrigh mail

    pittendr@illinois.edu

    Affiliation: Department of Entomology, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America

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  • Published: April 20, 2011
  • DOI: 10.1371/journal.pone.0018215

About the Authors

Lijie Sun, Hong-Mei Li, Kent R. Walters Jr., Weilin Sun, Barry R. Pittendrigh
Department of Entomology, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America
Lijie Sun
Synthetic Biology & Bioenergy, J. Craig Venter Institute, San Diego, California, United States of America
Lijie Sun, Venu M. Margam, Yueh-Feng Li
Department of Entomology, Purdue University, West Lafayette, Indiana, United States of America
Manfredo J. Seufferheld
Department of Crop Sciences, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America
Amber Jannasch, Naomi Diaz, Catherine P. Riley
Metabolomics Profiling Facility at Bindley Bioscience Center, Purdue University, West Lafayette, Indiana, United States of America
Yueh-Feng Li
Chung Hwa College of Medical Technology, Jen-Te Hsiang, Tainan, Taiwan
William M. Muir
Department of Animal Sciences, Purdue University, West Lafayette, Indiana, United States of America
Jun Xie
Department of Statistics, Purdue University, West Lafayette, Indiana, United States of America
Jing Wu
Department of Statistics, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America
Fan Zhang, Jake Y. Chen
School of Informatics, Indiana University, Indianapolis, Indiana, United States of America
Eric L. Barker
Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana, United States of America
Jiri Adamec
Department of Biochemistry, University of Nebraska, Lincoln, Nebraska, United States of America

Corresponding Author

Email: pittendr@illinois.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LS HML MJS KW VM AJ ND CPR WS YFL WMM JX FZ JYC ELB JA BRP. Performed the experiments: LS HML KW VM AJ ND CPR WS YFL FZ. Analyzed the data: LS HML MJS KW WS WMM JX FZ JYC ELB JA BRP. Contributed reagents/materials/analysis tools: MJS WMM JX JW FZ JYC JA BRP. Wrote the paper: LS HML MJS KW AJ ND CPR WMM JX JW FZ JYC ELB JA BRP.