About the Authors

Ume L. Abbas

abbasu@ccf.org

Affiliation Department of Infectious Diseases, Cleveland Clinic Foundation, Cleveland, Ohio, United States of America

Gregory Hood

Affiliation Pittsburgh Supercomputing Center, Pittsburgh, Pennsylvania, United States of America

Arthur W. Wetzel

Affiliation Pittsburgh Supercomputing Center, Pittsburgh, Pennsylvania, United States of America

John W. Mellors

Affiliation Division of Infectious Diseases, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Competing Interests

John W. Mellors reports that he is a consultant to Gilead Sciences, Merck, and RFS Pharmaceuticals, has received grant support from Merck, and owns share options in RFS Pharmaceuticals. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Wrote the paper: ULA.Model formulation: ULA JWM. Model analyses: ULA. Computer programming and multivariate sensitivity analyses at the Pittsburgh Supercomputing Center: GH AWW. Interpreted results and edited the manuscript: JWM.