About the Authors

Jan Dörr

jan-markus.doerr@charite.de

Affiliation NeuroCure Clinical Research Center, Charité - Universitaetsmedizin Berlin, Berlin, Germany

Klaus D. Wernecke

Affiliation Sophisticated Statistical Analysis GmbH and Charité - Universitaetsmedizin Berlin, Berlin, Germany

Markus Bock

Affiliation NeuroCure Clinical Research Center, Charité - Universitaetsmedizin Berlin, Berlin, Germany

Gunnar Gaede

Affiliation NeuroCure Clinical Research Center, Charité - Universitaetsmedizin Berlin, Berlin, Germany

Jens T. Wuerfel

Affiliation Institute of Neuroradiology, University Luebeck, Luebeck, Germany

Caspar F. Pfueller

Affiliation NeuroCure Clinical Research Center, Charité - Universitaetsmedizin Berlin, Berlin, Germany

Judith Bellmann-Strobl

Affiliations NeuroCure Clinical Research Center, Charité - Universitaetsmedizin Berlin, Berlin, Germany, Experimental and Clinical Research Center, Charité - Universitaetsmedizin Berlin and Max-Delbrück Center for Molecular Medicine Berlin, Berlin, Germany

Alina Freing

Affiliation NeuroCure Clinical Research Center, Charité - Universitaetsmedizin Berlin, Berlin, Germany

Alexander U. Brandt

Contributed equally to this work with: Alexander U. Brandt, Paul Friedemann

Affiliations NeuroCure Clinical Research Center, Charité - Universitaetsmedizin Berlin, Berlin, Germany, gfnmediber GmbH, Berlin, Germany

Paul Friedemann

Contributed equally to this work with: Alexander U. Brandt, Paul Friedemann

Affiliations NeuroCure Clinical Research Center, Charité - Universitaetsmedizin Berlin, Berlin, Germany, Experimental and Clinical Research Center, Charité - Universitaetsmedizin Berlin and Max-Delbrück Center for Molecular Medicine Berlin, Berlin, Germany

Competing Interests

Alexander U. Brandt is deputy CEO of gfnmediber GmbH and guest scientist at the NeuroCure Clinical Research Center (NCRC). Alexander U Brandt contributed to the study merely in his role of a guest scientist at the NCRC. Klaus-Dieter Wernecke is CEO of Sophisticated Statistical Analysis (SoStAna) and scientist at the Charité, Berlin. Klaus-Dieter Wernecke contributed to the study merely in his role as a scientist at the Charité. There are no patents, products in development or marketed products to declare with the current study and these affiliations did not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials. All other authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: FP AUB JTW. Performed the experiments: JD MB GG CFP JBS. Analyzed the data: KDW AUB JD AF. Contributed reagents/materials/analysis tools: KDW JTW AF. Wrote the paper: JD AUB. Revised article for important intellectual content: JD KDW MB GG JTW CFP JBS AF AUB FP.