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Research Article

Increased Breadth and Depth of Cytotoxic T Lymphocytes Responses against HIV-1-B Nef by Inclusion of Epitope Variant Sequences

  • Morgane Rolland equal contributor mail,

    equal contributor Contributed equally to this work with: Morgane Rolland, Nicole Frahm

    mrolland@hivresearch.org

    Affiliation: Department of Microbiology, University of Washington, Seattle, Washington, United States of America

    Current address: Military HIV Research Program, Henry M. Jackson Foundation, Rockville, Maryland, United States of America

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  • Nicole Frahm equal contributor,

    equal contributor Contributed equally to this work with: Morgane Rolland, Nicole Frahm

    Affiliation: Massachussets General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

    Current address: Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

    X
  • David C. Nickle,

    Affiliation: Department of Microbiology, University of Washington, Seattle, Washington, United States of America

    X
  • Nebojsa Jojic,

    Affiliation: AIDS Research Institute IrsiCaixa - HIVACAT, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain

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  • Wenjie Deng,

    Affiliation: Department of Microbiology, University of Washington, Seattle, Washington, United States of America

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  • Todd M. Allen,

    Affiliation: Massachussets General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Christian Brander,

    Affiliations: Massachussets General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, AIDS Research Institute IrsiCaixa - HIVACAT, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain, Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain

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  • David E. Heckerman,

    Affiliation: Microsoft Research, Redmond, Washington, United States of America

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  • James I. Mullins

    Affiliation: Department of Microbiology, University of Washington, Seattle, Washington, United States of America

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  • Published: March 28, 2011
  • DOI: 10.1371/journal.pone.0017969

About the Authors

Morgane Rolland, David C. Nickle, Wenjie Deng, James I. Mullins
Department of Microbiology, University of Washington, Seattle, Washington, United States of America
Nicole Frahm, Todd M. Allen, Christian Brander
Massachussets General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
Nebojsa Jojic, Christian Brander
AIDS Research Institute IrsiCaixa - HIVACAT, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain
Christian Brander
Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain
David E. Heckerman
Microsoft Research, Redmond, Washington, United States of America

Corresponding Author

Email: mrolland@hivresearch.org

Competing Interests

David E. Heckerman is an employee of Microsoft Research. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: MR NF DCN NJ CB DEH JIM. Performed the experiments: MR NF DCN NJ DEH. Analyzed the data: MR NF CB DEH JIM. Contributed reagents/materials/analysis tools: WD TMA. Wrote the paper: MR NF CB JIM.