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Research Article

The Base Excision Repair Pathway Is Required for Efficient Lentivirus Integration

  • Kristine E. Yoder mail,

    yoder.176@osu.edu (KEY); rfishel@osu.edu (RF)

    Affiliation: Molecular Virology, Immunology, and Medical Genetics, Human Cancer Genetics, The Ohio State University Medical Center and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, United States of America

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  • Amy Espeseth,

    Affiliation: Department of Antiviral Research, Merck Research Laboratories, West Point, Pennsylvania, United States of America

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  • Xiao-hong Wang,

    Affiliation: University of Pittsburgh Cancer Institute, Hillman Cancer Center, Pittsburgh, Pennsylvania, United States of America

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  • Qingming Fang,

    Affiliation: University of Pittsburgh Cancer Institute, Hillman Cancer Center, Pittsburgh, Pennsylvania, United States of America

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  • Maria Teresa Russo,

    Affiliation: Department of Environment and Primary Prevention, Istituto Superiore di Sanità, Rome, Italy

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  • R. Stephen Lloyd,

    Affiliation: Center for Research on Occupational and Environmental Toxicology, Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, Oregon, United States of America

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  • Daria Hazuda,

    Affiliation: Department of Antiviral Research, Merck Research Laboratories, West Point, Pennsylvania, United States of America

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  • Robert W. Sobol,

    Affiliations: Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, University of Pittsburgh Cancer Institute, Hillman Cancer Center, Pittsburgh, Pennsylvania, United States of America, Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania, United States of America

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  • Richard Fishel mail

    yoder.176@osu.edu (KEY); rfishel@osu.edu (RF)

    Affiliations: Molecular Virology, Immunology, and Medical Genetics, Human Cancer Genetics, The Ohio State University Medical Center and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, United States of America, Physics Department, The Ohio State University, Columbus, Ohio, United States of America

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  • Published: March 23, 2011
  • DOI: 10.1371/journal.pone.0017862

About the Authors

Kristine E. Yoder, Richard Fishel
Molecular Virology, Immunology, and Medical Genetics, Human Cancer Genetics, The Ohio State University Medical Center and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, United States of America
Richard Fishel
Physics Department, The Ohio State University, Columbus, Ohio, United States of America
Amy Espeseth, Daria Hazuda
Department of Antiviral Research, Merck Research Laboratories, West Point, Pennsylvania, United States of America
Maria Teresa Russo
Department of Environment and Primary Prevention, Istituto Superiore di Sanità, Rome, Italy
R. Stephen Lloyd
Center for Research on Occupational and Environmental Toxicology, Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, Oregon, United States of America
Robert W. Sobol
Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
Xiao-hong Wang, Qingming Fang, Robert W. Sobol
University of Pittsburgh Cancer Institute, Hillman Cancer Center, Pittsburgh, Pennsylvania, United States of America
Robert W. Sobol
Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania, United States of America

Corresponding Authors

Competing Interests

The authors have read the journal's policy and have the following conflict: Authors A. Espeseth and D. Hazuda are employed by Merck Research Laboratories. All other authors declare that no competing interests exist. All authors agree to make freely available any materials and information described in this publication that are reasonably requested by others for the purpose of academic, non-commercial research.

Author Contributions

Conceived and designed the experiments: KEY AE DH RWS RF. Performed the experiments: KEY XW QF. Analyzed the data: KEY AE RSL DH RWS RF. Contributed reagents/materials/analysis tools: MTR RSL RWS. Wrote the paper: KEY AE RSL RWS RF .