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Research Article

Embryonic Senescence and Laminopathies in a Progeroid Zebrafish Model

  • Eriko Koshimizu,

    Affiliations: Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States of America, Graduate School of Marine Science and Technology, University of Marine Science and Technology, Tokyo, Japan

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  • Shintaro Imamura,

    Affiliation: Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States of America

    Current address: National Research Institute of Fisheries Science, Yokohama, Japan

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  • Jie Qi,

    Affiliations: Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, Florida, United States of America

    Current address: Ocean University of China, Qingdao, China

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  • Jamal Toure,

    Affiliation: Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Delgado M. Valdez Jr,

    Affiliation: Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, Florida, United States of America

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  • Christopher E. Carr,

    Affiliation: Department of Earth, Atmospheric and Planetary Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Jun-ichi Hanai,

    Affiliation: Division of Nephrology, Interdisciplinary Medicine and Biotechnology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Shuji Kishi mail

    kishi@scripps.edu

    Affiliations: Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, Florida, United States of America

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  • Published: March 30, 2011
  • DOI: 10.1371/journal.pone.0017688

About the Authors

Eriko Koshimizu, Shintaro Imamura, Jie Qi, Jamal Toure, Shuji Kishi
Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States of America
Eriko Koshimizu
Graduate School of Marine Science and Technology, University of Marine Science and Technology, Tokyo, Japan
Christopher E. Carr
Department of Earth, Atmospheric and Planetary Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
Jun-ichi Hanai
Division of Nephrology, Interdisciplinary Medicine and Biotechnology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
Jie Qi, Delgado M. Valdez Jr, Shuji Kishi
Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, Florida, United States of America

Corresponding Author

Email: kishi@scripps.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: EK SI JH SK. Performed the experiments: EK SI JQ JT DMV SK. Analyzed the data: EK SI CEC SK. Contributed reagents/materials/analysis tools: CEC SK. Wrote the paper: EK SK.