About the Authors

Ivanny Marchant

ivanny.marchant@uv.cl

Affiliations Departamento de Pre-clínicas, Escuela de Medicina, Universidad de Valparaíso, Valparaíso, Chile, IMTh – Institute for Theoretical Medicine, Lyon, France, Université Lyon 1, CNRS, UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, Lyon, France

Patrice Nony

Affiliations IMTh – Institute for Theoretical Medicine, Lyon, France, Université Lyon 1, CNRS, UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, Lyon, France, Service de Pharmacologie Clinique, Hop L Pradel, Centre Hospitalier Universitaire Lyon, Lyon, France

Michel Cucherat

Affiliation Université Lyon 1, CNRS, UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, Lyon, France

Jean-Pierre Boissel

Affiliations Novadiscovery, Lyon, France, Novacare, Lyon, France

S. Randall Thomas

Affiliation IR4M (UMR8081), Université Paris-Sud, CNRS, Orsay, France

Theodora Bejan-Angoulvant

Affiliations IMTh – Institute for Theoretical Medicine, Lyon, France, Université Lyon 1, CNRS, UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, Lyon, France, INSERM, CIC 201, EPICIME, Lyon, France, Service de Pharmacologie Clinique, Hop L Pradel, Centre Hospitalier Universitaire Lyon, Lyon, France

Alexandra Laugerotte

Affiliations IMTh – Institute for Theoretical Medicine, Lyon, France, Université Lyon 1, CNRS, UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, Lyon, France, INSERM, CIC 201, EPICIME, Lyon, France

Riad Kahoul

Affiliations Université Lyon 1, CNRS, UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, Lyon, France, Novadiscovery, Lyon, France, Novacare, Lyon, France

François Gueyffier

Affiliations IMTh – Institute for Theoretical Medicine, Lyon, France, Université Lyon 1, CNRS, UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, Lyon, France, INSERM, CIC 201, EPICIME, Lyon, France, Service de Pharmacologie Clinique, Hop L Pradel, Centre Hospitalier Universitaire Lyon, Lyon, France

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: IM J-PB FG . Performed the experiments: IM TB-A AL RK. Analyzed the data: IM FG J-PB SRT. Contributed reagents/materials/analysis tools: IM PN MC. Wrote the manuscript: IM FG. Revised the article critically for important intellectual content: IM PN MC J-PB SRT FG.