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Research Article

Genome-Wide Association Study Identifies Genetic Loci Associated with Iron Deficiency

  • Christine E. McLaren mail,

    cmclaren@uci.edu

    Affiliation: Department of Epidemiology, University of California Irvine, Irvine, California, United States of America

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  • Chad P. Garner,

    Affiliation: Department of Epidemiology, University of California Irvine, Irvine, California, United States of America

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  • Clare C. Constantine,

    Affiliation: Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, The University of Melbourne, Melbourne, Australia

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  • Stela McLachlan,

    Affiliation: Nutritional Sciences and Toxicology, University of California, Berkeley, California, United States of America

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  • Chris D. Vulpe,

    Affiliation: Nutritional Sciences and Toxicology, University of California, Berkeley, California, United States of America

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  • Beverly M. Snively,

    Affiliation: Division of Public Health Sciences, Department of Biostatistical Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America

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  • Victor R. Gordeuk,

    Affiliation: Department of Medicine, Howard University, Washington, D.C., United States of America

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  • Debbie A. Nickerson,

    Affiliation: Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

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  • James D. Cook,

    Affiliation: Department of Medicine, The University of Kansas Medical Center, Kansas City, Kansas, United States of America

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  • Catherine Leiendecker-Foster,

    Affiliation: Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, United States of America

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  • Kenneth B. Beckman,

    Affiliation: Department of Genetics, Cell Biology and Developmental Biology, University of Minnesota, Minneapolis, Minnesota, United States of America

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  • John H. Eckfeldt,

    Affiliation: Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, United States of America

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  • Lisa F. Barcellos,

    Affiliation: School of Public Health, University of California, Berkeley, California, United States of America

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  • Joseph A. Murray,

    Affiliation: Division of Gastroenterology/Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America

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  • Paul C. Adams,

    Affiliation: London Health Sciences Centre, London, Ontario, Canada

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  • Ronald T. Acton,

    Affiliation: Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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  • Anthony A. Killeen,

    Affiliation: Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, United States of America

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  • Gordon D. McLaren

    Affiliations: Department of Veterans Affairs Long Beach Healthcare System, Long Beach, California, United States of America, Division of Hematology/Oncology, Department of Medicine, University of California Irvine, Irvine, California, United States of America

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  • Published: March 31, 2011
  • DOI: 10.1371/journal.pone.0017390

About the Authors

Christine E. McLaren, Chad P. Garner
Department of Epidemiology, University of California Irvine, Irvine, California, United States of America
Clare C. Constantine
Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, The University of Melbourne, Melbourne, Australia
Stela McLachlan, Chris D. Vulpe
Nutritional Sciences and Toxicology, University of California, Berkeley, California, United States of America
Beverly M. Snively
Division of Public Health Sciences, Department of Biostatistical Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America
Victor R. Gordeuk
Department of Medicine, Howard University, Washington, D.C., United States of America
Debbie A. Nickerson
Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America
James D. Cook
Department of Medicine, The University of Kansas Medical Center, Kansas City, Kansas, United States of America
Catherine Leiendecker-Foster, John H. Eckfeldt, Anthony A. Killeen
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, United States of America
Kenneth B. Beckman
Department of Genetics, Cell Biology and Developmental Biology, University of Minnesota, Minneapolis, Minnesota, United States of America
Lisa F. Barcellos
School of Public Health, University of California, Berkeley, California, United States of America
Joseph A. Murray
Division of Gastroenterology/Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
Paul C. Adams
London Health Sciences Centre, London, Ontario, Canada
Ronald T. Acton
Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
Gordon D. McLaren
Department of Veterans Affairs Long Beach Healthcare System, Long Beach, California, United States of America
Gordon D. McLaren
Division of Hematology/Oncology, Department of Medicine, University of California Irvine, Irvine, California, United States of America

Corresponding Author

Email: cmclaren@uci.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CEM CPG CCC GDM. Performed the experiments: CLF KBB JAM. Analyzed the data: CPG. Contributed reagents/materials/analysis tools: KBB. Wrote the paper: CEM CPG CCC SM CDV BMS VRG DAN JDC CLF JHE LFB JAM PCA RTA AAK GDM.