The Induction of MicroRNA Targeting IRS-1 Is Involved in the Development of Insulin Resistance under Conditions of Mitochondrial Dysfunction in Hepatocytes

Hyun Su Ryu; Seung-Yoon Park; Duan Ma; Jin Zhang; Wan Lee

doi:10.1371/journal.pone.0017343

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Open Access

Peer-reviewed

Research Article

The Induction of MicroRNA Targeting IRS-1 Is Involved in the Development of Insulin Resistance under Conditions of Mitochondrial Dysfunction in Hepatocytes

Hyun Su Ryu ,

Contributed equally to this work with: Hyun Su Ryu, Seung-Yoon Park

Affiliation Department of Biochemistry, Dongguk University College of Medicine, Kyungju, Korea
⨯
Seung-Yoon Park ,

Contributed equally to this work with: Hyun Su Ryu, Seung-Yoon Park

Affiliation Department of Biochemistry, Dongguk University College of Medicine, Kyungju, Korea
⨯
Duan Ma,

Affiliation Key Lab of Molecular Medicine, Shanghai Medical College, Institutes of Biomedical Sciences, Fudan University, Shanghai, China
⨯
Jin Zhang,

Affiliation Key Lab of Molecular Medicine, Shanghai Medical College, Institutes of Biomedical Sciences, Fudan University, Shanghai, China
⨯
Wan Lee

* E-mail: wanlee@dongguk.ac.kr

Affiliation Department of Biochemistry, Dongguk University College of Medicine, Kyungju, Korea
⨯

The Induction of MicroRNA Targeting IRS-1 Is Involved in the Development of Insulin Resistance under Conditions of Mitochondrial Dysfunction in Hepatocytes

Hyun Su Ryu,
Seung-Yoon Park,
Duan Ma,
Jin Zhang,
Wan Lee

Published: March 25, 2011
https://doi.org/10.1371/journal.pone.0017343

About the Authors

Hyun Su Ryu

Contributed equally to this work with: Hyun Su Ryu, Seung-Yoon Park

Affiliation Department of Biochemistry, Dongguk University College of Medicine, Kyungju, Korea

Seung-Yoon Park

Contributed equally to this work with: Hyun Su Ryu, Seung-Yoon Park

Affiliation Department of Biochemistry, Dongguk University College of Medicine, Kyungju, Korea

Duan Ma

Affiliation Key Lab of Molecular Medicine, Shanghai Medical College, Institutes of Biomedical Sciences, Fudan University, Shanghai, China

Jin Zhang

Affiliation Key Lab of Molecular Medicine, Shanghai Medical College, Institutes of Biomedical Sciences, Fudan University, Shanghai, China

Wan Lee

* E-mail: wanlee@dongguk.ac.kr

Affiliation Department of Biochemistry, Dongguk University College of Medicine, Kyungju, Korea

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: WL SP. Performed the experiments: HR SP JZ DM. Analyzed the data: WL HR SP DM JZ. Contributed reagents/materials/analysis tools: WL HR SP DM JZ. Wrote the paper: WL.

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Mitochondria
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Hepatocytes
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MicroRNAs
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Insulin resistance
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Mitochondrial DNA
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Insulin signaling
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Plasmid construction
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Insulin
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