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Research Article

Distinct Cerebrospinal Fluid Proteomes Differentiate Post-Treatment Lyme Disease from Chronic Fatigue Syndrome

  • Steven E. Schutzer equal contributor mail,

    equal contributor Contributed equally to this work with: Steven E. Schutzer, Thomas E. Angel, Tao Liu

    schutzer@umdnj.edu

    Affiliation: Department of Medicine, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark, New Jersey, United States of America

    X
  • Thomas E. Angel equal contributor,

    equal contributor Contributed equally to this work with: Steven E. Schutzer, Thomas E. Angel, Tao Liu

    Affiliation: Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America

    X
  • Tao Liu equal contributor,

    equal contributor Contributed equally to this work with: Steven E. Schutzer, Thomas E. Angel, Tao Liu

    Affiliation: Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America

    X
  • Athena A. Schepmoes,

    Affiliation: Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America

    X
  • Therese R. Clauss,

    Affiliation: Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America

    X
  • Joshua N. Adkins,

    Affiliation: Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America

    X
  • David G. Camp II,

    Affiliation: Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America

    X
  • Bart K. Holland,

    Affiliation: Division of Biostatistics and Epidemiology, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark, New Jersey, United States of America

    X
  • Jonas Bergquist,

    Affiliation: Department of Physical and Analytical Chemistry, Uppsala University, Uppsala, Sweden

    X
  • Patricia K. Coyle,

    Affiliation: Department of Neurology, State University of New York-Stony Brook, Stony Brook, New York, United States of America

    X
  • Richard D. Smith,

    Affiliation: Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America

    X
  • Brian A. Fallon,

    Affiliation: Department of Psychiatry, Columbia University Medical Center, New York, New York, United States of America

    X
  • Benjamin H. Natelson

    Affiliations: Department of Neurology, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark, New Jersey, United States of America, Department of Pain Medicine and Palliative Care and Beth Israel Medical Center, Albert Einstein School of Medicine, Bronx, New York, United States of America

    X
  • Published: February 23, 2011
  • DOI: 10.1371/journal.pone.0017287

About the Authors

Steven E. Schutzer
Department of Medicine, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark, New Jersey, United States of America
Benjamin H. Natelson
Department of Neurology, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark, New Jersey, United States of America
Bart K. Holland
Division of Biostatistics and Epidemiology, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark, New Jersey, United States of America
Thomas E. Angel, Tao Liu, Athena A. Schepmoes, Therese R. Clauss, Joshua N. Adkins, David G. Camp II, Richard D. Smith
Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America
Jonas Bergquist
Department of Physical and Analytical Chemistry, Uppsala University, Uppsala, Sweden
Patricia K. Coyle
Department of Neurology, State University of New York-Stony Brook, Stony Brook, New York, United States of America
Brian A. Fallon
Department of Psychiatry, Columbia University Medical Center, New York, New York, United States of America
Benjamin H. Natelson
Department of Pain Medicine and Palliative Care and Beth Israel Medical Center, Albert Einstein School of Medicine, Bronx, New York, United States of America

Corresponding Author

Email: schutzer@umdnj.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SES TEA TL RDS. Performed the experiments: SES TEA TL AAS TRC. Analyzed the data: SES TEA TL JNA RDS PKC BAF BHN DGC BKH JB. Contributed reagents/materials/analysis tools: SES TEA TL JNA RDS PKC BAF BHN DGC. Wrote the paper: SES TEA TL JNA RDS PKC BAF BHN DGC.