The Nuclear Guanine Nucleotide Exchange Factors Ect2 and Net1 Regulate RhoB-Mediated Cell Death after DNA Damage

Melissa C. Srougi; Keith Burridge

doi:10.1371/journal.pone.0017108

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Open Access

Peer-reviewed

Research Article

The Nuclear Guanine Nucleotide Exchange Factors Ect2 and Net1 Regulate RhoB-Mediated Cell Death after DNA Damage

Melissa C. Srougi ,

* E-mail: melissa_srougi@med.unc.edu

Affiliations Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, North Carolina, United States of America, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, United States of America
⨯
Keith Burridge

Affiliations Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, North Carolina, United States of America, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, United States of America
⨯

The Nuclear Guanine Nucleotide Exchange Factors Ect2 and Net1 Regulate RhoB-Mediated Cell Death after DNA Damage

Melissa C. Srougi,
Keith Burridge

Published: February 23, 2011
https://doi.org/10.1371/journal.pone.0017108

About the Authors

Melissa C. Srougi

* E-mail: melissa_srougi@med.unc.edu

Affiliations Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, North Carolina, United States of America, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, United States of America

Keith Burridge

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MCS KB. Performed the experiments: MCS. Analyzed the data: MCS KB. Contributed reagents/materials/analysis tools: MCS KB. Wrote the manuscript: MCS. Revised the manuscript: KB.

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DNA damage
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Guanine nucleotide exchange factors
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Transfection
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Cell death
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Small interfering RNA
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Breast cancer
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Phosphorylation
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Apoptosis
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