About the Authors

Mary S. Campbell

Affiliation Department of Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America

James I. Mullins

jmullins@uw.edu

Affiliations Department of Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America, Department of Microbiology, University of Washington School of Medicine, Seattle, Washington, United States of America, Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America

James P. Hughes

Affiliation Department of Biostatistics, University of Washington School of Medicine, Seattle, Washington, United States of America

Connie Celum

Affiliations Department of Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America, Department of Global Health, University of Washington School of Medicine, Seattle, Washington, United States of America

Kim G. Wong

Affiliation Department of Microbiology, University of Washington School of Medicine, Seattle, Washington, United States of America

Dana N. Raugi

Affiliation Department of Microbiology, University of Washington School of Medicine, Seattle, Washington, United States of America

Stefanie Sorensen

Affiliation Department of Microbiology, University of Washington School of Medicine, Seattle, Washington, United States of America

Julia N. Stoddard

Affiliation Department of Microbiology, University of Washington School of Medicine, Seattle, Washington, United States of America

Hong Zhao

Affiliation Department of Microbiology, University of Washington School of Medicine, Seattle, Washington, United States of America

Wenjie Deng

Affiliation Department of Microbiology, University of Washington School of Medicine, Seattle, Washington, United States of America

Erin Kahle

Affiliation Department of Global Health, University of Washington School of Medicine, Seattle, Washington, United States of America

Dana Panteleeff

Affiliation Department of Global Health, University of Washington School of Medicine, Seattle, Washington, United States of America

Jared M. Baeten

Affiliations Department of Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America, Department of Global Health, University of Washington School of Medicine, Seattle, Washington, United States of America

Francine E. McCutchan

Affiliation Bill & Melinda Gates Foundation, Seattle, Washington, United States of America

Jan Albert

Affiliation Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden

Thomas Leitner

Affiliation Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America

Anna Wald

Affiliations Department of Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America, Department of Epidemiology, University of Washington School of Medicine, Seattle, Washington, United States of America, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Institute, Seattle Washington, United States of America

Lawrence Corey

Affiliations Department of Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America, Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Institute, Seattle Washington, United States of America

Jairam R. Lingappa

Affiliations Department of Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America, Department of Global Health, University of Washington School of Medicine, Seattle, Washington, United States of America, Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington, United States of America

for the Partners in Prevention HSV/HIV Transmission Study Team

Membership of the Partners in Prevention HSV/HIV Transmission Study Team are provided in the Acknowledgments.

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JIM MSC JPH JRJ. Performed the experiments: KGW DNR SS JNS HZ WD. Analyzed the data: MSC JIM JPH JMB FEM JA TL. Contributed reagents/materials/analysis tools: CC EK DP JRL AW LC. Wrote the paper: MSC JIM JRL JPH.