Advertisement
Research Article

Human Stiff-Person Syndrome IgG Induces Anxious Behavior in Rats

  • Christian Geis mail,

    Geis_C@klinik.uni-wuerzburg.de

    Affiliation: Department of Neurology, University of Würzburg, Würzburg, Germany

    X
  • Andreas Weishaupt,

    Affiliation: Department of Neurology, University of Würzburg, Würzburg, Germany

    X
  • Benedikt Grünewald,

    Affiliation: Department of Neurology, University of Würzburg, Würzburg, Germany

    X
  • Thomas Wultsch,

    Affiliation: Department of Psychiatry, University of Würzburg, Würzburg, Germany

    X
  • Andreas Reif,

    Affiliation: Department of Psychiatry, University of Würzburg, Würzburg, Germany

    X
  • Manfred Gerlach,

    Affiliation: Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, Würzburg, Germany

    X
  • Ron Dirkx,

    Affiliation: Molecular Diabetology, Carl Gustav Carus Medical School, Dresden University of Technology, Dresden, Germany

    X
  • Michele Solimena,

    Affiliation: Molecular Diabetology, Carl Gustav Carus Medical School, Dresden University of Technology, Dresden, Germany

    X
  • Daniela Perani,

    Affiliations: Division of Neuroscience, Vita-Salute San Raffaele University, Milan, Italy, Division of Neuroscience, Department of Nuclear Medicine, Scientific Institute San Raffaele, Milan, Italy

    X
  • Manfred Heckmann,

    Affiliations: Institute of Physiology, University of Würzburg, Würzburg, Germany, Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, University of Würzburg, Würzburg, Germany

    X
  • Klaus V. Toyka,

    Affiliation: Department of Neurology, University of Würzburg, Würzburg, Germany

    X
  • Franco Folli,

    Affiliation: Diabetes Division, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, United States of America

    X
  • Claudia Sommer

    Affiliation: Department of Neurology, University of Würzburg, Würzburg, Germany

    X
  • Published: February 08, 2011
  • DOI: 10.1371/journal.pone.0016775

About the Authors

Christian Geis, Andreas Weishaupt, Benedikt Grünewald, Klaus V. Toyka, Claudia Sommer
Department of Neurology, University of Würzburg, Würzburg, Germany
Thomas Wultsch, Andreas Reif
Department of Psychiatry, University of Würzburg, Würzburg, Germany
Manfred Gerlach
Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, Würzburg, Germany
Manfred Heckmann
Institute of Physiology, University of Würzburg, Würzburg, Germany
Manfred Heckmann
Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, University of Würzburg, Würzburg, Germany
Ron Dirkx, Michele Solimena
Molecular Diabetology, Carl Gustav Carus Medical School, Dresden University of Technology, Dresden, Germany
Daniela Perani
Division of Neuroscience, Vita-Salute San Raffaele University, Milan, Italy
Daniela Perani
Division of Neuroscience, Department of Nuclear Medicine, Scientific Institute San Raffaele, Milan, Italy
Franco Folli
Diabetes Division, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, United States of America

Corresponding Author

Email: Geis_C@klinik.uni-wuerzburg.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CG KVT MH CS. Performed the experiments: CG AW BG TW MG RD DP. Analyzed the data: CG MS MH BG KVT CS AR RD DP. Contributed reagents/materials/analysis tools: FF DP MG. Wrote the paper: CG KVT FF CS.