About the Authors

Elina Salmela

Affiliations Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland, Department of Medical Genetics, University of Helsinki, Helsinki, Finland, Folkhälsan Institute of Genetics, Helsinki, Finland

Tuuli Lappalainen

Affiliations Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland, Department of Medical Genetics, University of Helsinki, Helsinki, Finland, Folkhälsan Institute of Genetics, Helsinki, Finland, Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland

Jianjun Liu

Affiliation Human Genetics, Genome Institute of Singapore, Singapore, Singapore

Pertti Sistonen

Affiliation Finnish Red Cross Blood Transfusion Service, Helsinki, Finland

Peter M. Andersen

Affiliation Department of Neurology, Umeå University Hospital, University of Umeå, Umeå, Sweden

Stefan Schreiber

Affiliation Department of General Internal Medicine, Institute for Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany

Marja-Liisa Savontaus

Affiliation Department of Medical Genetics, University of Turku, Turku, Finland

Kamila Czene

Affiliation Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

Päivi Lahermo

Affiliation Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland

Per Hall

Affiliation Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

Juha Kere

juha.kere@ki.se

Affiliations Department of Medical Genetics, University of Helsinki, Helsinki, Finland, Folkhälsan Institute of Genetics, Helsinki, Finland, Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden, Clinical Research Centre, Karolinska University Hospital, Huddinge, Sweden

Competing Interests

The authors have read the journal's policy and have the following conflicts: Prof. Schreiber has been a member of Applied Biosystems scientific advisory board. No Applied Biosystems product or services were used in this study. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: ES TL JL PL PH JK. Performed the experiments: ES TL JL. Analyzed the data: ES TL. Contributed reagents/materials/analysis tools: JL PS PMA SS MLS KC PH. Wrote the paper: ES TL.